Table 1 Investigation Results for Twin 1 and Twin 2
From: A familial case of Kikuchi-Fujimoto disease in dizygotic twins
Test | Twin 1 | Twin 2 | Normal Range | |
|---|---|---|---|---|
Full Blood Count | Haemoglobin | 106 (L) | 104 (L) | 115–150 g/L |
White cell count | 3.4 (L) | 3.6 (L) | 4.5–13.5 × 10^9/L | |
Platelet count | 199 | 262 | 150–600 × 10^9/L | |
Neutrophil count | 1.5 | 1.9 | 1.5–8.0 × 10^9/L | |
Lymphocyte count | 1.5 | 1.4 | 1.0–4.0 × 10^9/L | |
Liver Function Test | Within normal limits | Within normal limits | ||
Electrolytes/Urea/Creatinine | Within normal limits | Within normal limits | ||
C-reactive Protein | 60 (H) | 82.2 (H) | 0–10 mg/L | |
Erythrocyte Sedimentation Rate | 101 (H) | 50 (H) | 0–20 mm/hr | |
ANA screen | Negative | Negative | ||
ENA screen | Not detected | Not detected | ||
Anti-dsDNA antibodies | Negative | Negative | ||
Complement C3 | 1.68 | 1.43 | 0.75–1.75 g/L | |
Complement C4 | 0.34 | 0.32 | 0.13–0.52 g/L | |
Urate | 0.24 | 0.30 | 0.14–0.36 mmol/L | |
Lactate Dehydrogenase | 586 | 266 (L) | 313–618 U/L | |
Immunoglobulins | IgG | N/A | 4.33 (L) | 6.24–14.40 g/L |
IgA | N/A | < 0.06 (L) | 0.59–3.96 | |
IgM | N/A | 0.73 | 0.48–3.04 | |
IgE | N/A | < 20 | 0–200 IU/mL | |
Toxoplasma serology | IgM/IgG negative | IgM/IgG negative | ||
EBV serology | IgM/IgG negative | IgM/IgG negative | ||
Other Infective serology | Nil | Mycoplasma IgM positive, RSV PCR positive | ||
Histopathology | Histiocytic necrosis, no bacteria on gram stain, no AFB on ZN, no fungal elements on PAS | Histiocytic necrosis, no bacteria on gram stain, no AFB on ZN, no fungal elements on PAS, flow cytometry showed no abnormal cell population | ||
Imaging | CT: Extensive cervical lymphadenopathy with no other focus | Ultrasound: Multiple enlarged lymph nodes in the left cervical chain with increased vascularity, largest measures 20 × 13 mm | ||
HLA Class I | A | 02:01, 03:02 | 02:01, 03:02 | |
B | 08:01, 35:08 | 08:01, 35:08 | ||
C | 04:01, 07:02 | 04:01, 07:02 | ||
HLA Class II | DRB1 | 03:01, 07:01 | 03:01, 07:01 | |
DRB3 | 02:02 | 02:02 | ||
DRB4 | 01:03 | 01:03 | ||
DPB1 | 04:01, 23:01 | 04:01, 23:01 | ||
DQB1 | 02:01, 02:02 | 02:01, 02:02 | ||