Table 1 Desensitization to anakinra schedule. Desensitization pre medication: cetirizine 10 mg twice a day and oral metilprednisolone 4 mg twice a day
TIME INTERVAL (minutes) | DOSE (mg) | DILUTION (mg/mL) | |
|---|---|---|---|
Day 1 | 0 | 0,1 | 1 |
15 | 0,3 | 1 | |
30 | 0,6 | 1 | |
45 | 1 | 5 | |
60 | 2,5 | 5 | |
Day 2 | 0 | 2,5 | 5 |
30 | 3,75 | 5 | |
60 | 5 | 5 | |
90 | 6,25 | 10 | |
120 | 7,5 | 10 | |
Day 3 | 0 | 7,5 | 10 |
30 | 8,75 | 10 | |
60 | 10 | 20 | |
90 | 12,5 | 20 | |
Day 4 | 0 | 8,75 | 10 |
30 | 10 | 10 | |
60 | 12,5 | 20 | |
Day 5 | 0 | 12,5 | 20 |
30 | 15 | 20 | |
60 | 17,5 | 20 | |
Day 6 | 0 | 17,5 | 40 |
30 | 20 | 40 | |
60 | 22,5 | 40 | |
Day 7 | 0 | 22,5 | 40 |
30 | 25 | 40 | |
60 | 30 | 40 | |
Day 8 | 0 | 30 | 40 |
30 | 20 | 40 | |
60 | 30 | 40 | |
Day 9 | 0 | 30 | 60 |
30 | 20 | 60 | |
60 | 30 | 60 | |
Day 10 | 0 | 30 | 149 |
30 | 20 | 149 | |
60 | 30 | 149 | |
Day 11 | 0 | 40 | 149 |
30 | 40 | 149 |