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Table 4 Factors associated with ALL (Univariate and Multivariate analyses)

From: Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients)

 _____Univariate analysis_________Multivariate analysis 1a________Multivariate analysis 2b________Multivariate analysis 3c_____
βOR (95% CI)pβOR (95% CI)pβOR (95% CI)pβOR (95% CI)p
- Non-articular bone pain2.07.5 (2.9–19.8)<  0.0012.613.6 (3.2–57.4)0.001
- Non-articular bone pain and/or poor general state3.533.2 (12.5–87.6)<  0.0014.8124 (11.4–236)<  0.0014.6104 (6.3–172)0.001
- Neutrophils < 2 × 109/L1.86.1 (2.3–16.1)<  0.0013.950 (4.3–58)0.0024.6104 (3.4–327)0.008
- Platelets < 300 × 109/L2.07.6 (2.3–19.8)<  0.0012.614 (2.3–83.9)0.0043.431.8 (2.9–353)0.005
- Hepatomegaly, splenomegaly or lymphadenopathy4.9148 (31–696)<  0.0015.0154 (30–793)<  0.001
- Fever1.33.6 (2.1–6.5)<  0.0011.54.5 (1.9–10.5)0.01
Model performance measures d
 - AUC (95% CI)    0.94 (0.89–0.98) 0.96 (0.93–0.99)  0.96 (0.93–0.99) 
 - Sensitivity (95% CI)    0.85 (0.81–0.90) 0.83 (0.80–0.88)  0.83 (0.79–0.99) 
 - Specificity (95% CI)    0.93 (0.89–0.98) 0.95 (0.91–0.99)  0.95 (0.92–0.99) 
  1. β is the regression coefficient
  2. a: Multivariate analysis including “hepatomegaly, splenomegaly or lymphadenopathy”
  3. b: Multivariate analysis after excluding “hepatomegaly, splenomegaly or lymphadenopathy”
  4. c: Multivariate analysis after excluding “hepatomegaly, splenomegaly or lymphadenopathy”: model restricted to children with fever and/or increased inflammatory markers
  5. d: Values of apparent model performance obtained in the same subjects used for model development (AUC: area under the ROC curve)