Table 4 Factors associated with ALL (Univariate and Multivariate analyses)
_____Univariate analysis______ | ___Multivariate analysis 1a_____ | ___Multivariate analysis 2b_____ | ___Multivariate analysis 3c_____ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | OR (95% CI) | p | β | OR (95% CI) | p | β | OR (95% CI) | p | β | OR (95% CI) | p | |
- Non-articular bone pain | 2.0 | 7.5 (2.9–19.8) | < 0.001 | 2.6 | 13.6 (3.2–57.4) | 0.001 | – | – | – | – | – | – |
- Non-articular bone pain and/or poor general state | 3.5 | 33.2 (12.5–87.6) | < 0.001 | – | – | – | 4.8 | 124 (11.4–236) | < 0.001 | 4.6 | 104 (6.3–172) | 0.001 |
- Neutrophils < 2 × 109/L | 1.8 | 6.1 (2.3–16.1) | < 0.001 | – | – | – | 3.9 | 50 (4.3–58) | 0.002 | 4.6 | 104 (3.4–327) | 0.008 |
- Platelets < 300 × 109/L | 2.0 | 7.6 (2.3–19.8) | < 0.001 | – | – | – | 2.6 | 14 (2.3–83.9) | 0.004 | 3.4 | 31.8 (2.9–353) | 0.005 |
- Hepatomegaly, splenomegaly or lymphadenopathy | 4.9 | 148 (31–696) | < 0.001 | 5.0 | 154 (30–793) | < 0.001 | – | – | – | – | – | – |
- Fever | 1.3 | 3.6 (2.1–6.5) | < 0.001 | 1.5 | 4.5 (1.9–10.5) | 0.01 | – | – | – | – | – | – |
Model performance measures d | ||||||||||||
- AUC (95% CI) | 0.94 (0.89–0.98) | 0.96 (0.93–0.99) | 0.96 (0.93–0.99) | |||||||||
- Sensitivity (95% CI) | 0.85 (0.81–0.90) | 0.83 (0.80–0.88) | 0.83 (0.79–0.99) | |||||||||
- Specificity (95% CI) | 0.93 (0.89–0.98) | 0.95 (0.91–0.99) | 0.95 (0.92–0.99) | |||||||||