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Table 1 Demographical and clinical characteristics of patients with ALL or JIA

From: Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients)

 

ALL

JIA

p

N

49

98

 

Age, y (median [interquartile range])

7.3 [3.6–12.4]

7.6 [3.1–12.4]

NS**

Sex ratio, males per female

1.9

0.7

< 0.01*

Time to diagnosis, days (median [interquartile range])

57 [38;90]

121 [69;266]

< 0.001**

Pain location, n (%)

 Joint pain

40 (82)

98 (100)

NS*

 Non-articular pain

18 (37)

7 (7)

< 0.001*

Initial presentation, n (%)

  

< 0.05*

 Diffuse

42 (86)

68 (69)

 

 Localized

7 (14)

30 (31)

 

Symptoms at diagnosis, n (%)

 Fever

30 (61)

12 (12)

< 0.001*

 General symptoms

  Asthenia

34 (69)

7 (7)

< 0.001*

  Anorexia

12 (24)

4 (4)

< 0.001*

  Weight loss

10 (20)

4 (4)

< 0.01***

Clinical manifestations at diagnosis, n (%)

 Arthritis

1 (2)

80 (82)

< 0.001*

 Hepatomegaly, splenomegaly or lymphadenopathy

37 (76)

2 (2)

< 0.001*

  Hepatomegaly

23 (47)

1 (1)

< 0.001*

  Splenomegaly

15 (31)

1 (1)

< 0.001*

  Lymphadenopathy

28 (57)

1 (1)

< 0.001*

 Anemia signs

25 (51)

1 (1)

< 0.001*

 Thrombocytopenia signs

10 (20)

0 (0)

< 0.001***

 Neurological disorders

8 (16)

2 (2)

NS***

 Dermatological signs

1 (2)

7 (7)

NS***

  1. Univariate analysis with χ2 (*), Wilcoxon (**) or Fisher (***) tests
  2. ALL Acute lymphoblastic leukemia, JIA Juvenile idiopathic arthritis, NS Not significant
  3. “Time to diagnosis” was defined as the interval between the first symptoms and diagnosis
  4. The term “localized initial presentation” was used if only one bone or joint was painful at the onset of symptoms. In other cases, we considered the initial presentation as “diffuse”