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Table 1 Demographical and clinical characteristics of patients with ALL or JIA

From: Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients)

 ALLJIAp
N4998 
Age, y (median [interquartile range])7.3 [3.6–12.4]7.6 [3.1–12.4]NS**
Sex ratio, males per female1.90.7< 0.01*
Time to diagnosis, days (median [interquartile range])57 [38;90]121 [69;266]< 0.001**
Pain location, n (%)
 Joint pain40 (82)98 (100)NS*
 Non-articular pain18 (37)7 (7)< 0.001*
Initial presentation, n (%)  < 0.05*
 Diffuse42 (86)68 (69) 
 Localized7 (14)30 (31) 
Symptoms at diagnosis, n (%)
 Fever30 (61)12 (12)< 0.001*
 General symptoms
  Asthenia34 (69)7 (7)< 0.001*
  Anorexia12 (24)4 (4)< 0.001*
  Weight loss10 (20)4 (4)< 0.01***
Clinical manifestations at diagnosis, n (%)
 Arthritis1 (2)80 (82)< 0.001*
 Hepatomegaly, splenomegaly or lymphadenopathy37 (76)2 (2)< 0.001*
  Hepatomegaly23 (47)1 (1)< 0.001*
  Splenomegaly15 (31)1 (1)< 0.001*
  Lymphadenopathy28 (57)1 (1)< 0.001*
 Anemia signs25 (51)1 (1)< 0.001*
 Thrombocytopenia signs10 (20)0 (0)< 0.001***
 Neurological disorders8 (16)2 (2)NS***
 Dermatological signs1 (2)7 (7)NS***
  1. Univariate analysis with χ2 (*), Wilcoxon (**) or Fisher (***) tests
  2. ALL Acute lymphoblastic leukemia, JIA Juvenile idiopathic arthritis, NS Not significant
  3. “Time to diagnosis” was defined as the interval between the first symptoms and diagnosis
  4. The term “localized initial presentation” was used if only one bone or joint was painful at the onset of symptoms. In other cases, we considered the initial presentation as “diffuse”