Fig. 1From: Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variantsTimeline of canakinumab treatment, serum amyloid (SAA) concentration, and major disease flares. Bars show SAA concentrations (y-axis, ng/ml × 103, performed at Dynacare Laboratories, Canada; * exceeded upper limit of detection). Grey shading shows the start and end of periods (x-axis, month/year) of canakinumab treatment with doses (mg/kg) and duration (days) annotated above. Stars represent major disease flares lasting for more than 5 days and characterized by increased temperature, skin changes, abdominal pain and/or headachesBack to article page