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Table 1 (abstract A31). Change in HRQOL and Disability Within 3 Months of Starting Therapy in sJIA Patients*

From: Proceedings of the 2019 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Annual Scientific Meeting

Variable Placebo
n = 37
Tocilizumab
n = 75
Difference
Baseline Week 12 Baseline Week 12 At Week 12 In Change From Baseline to Week 12
CHAQ-DI 1.66 (0.82) 1.17 (0.99) 1.74 (0.79) 0.94 (0.77) –0.23 –0.31 (–0.62, 0.00)
 Activity 1.86 (1.00) 1.30 (1.18) 1.93 (0.99) 1.19 (1.11) –0.11 –0.18 (–0.61, 0.25)
 Rising 1.51 (0.96) 1.00 (1.08) 1.55 (0.93) 0.79 (0.92) –0.21 –0.25 (–0.67, 0.18)
 Dressing and grooming 1.84 (1.09) 1.27 (1.19) 1.91 (1.02) 1.18 (1.00) –0.09 –0.16 (–0.54, 0.22)
 Eating 1.22 (1.18) 0.89 (1.02) 1.49 (1.06) 0.64 (0.76) –0.25 –0.53 (–0.96, –0.09)
 Grip 1.65 (1.03) 1.11 (1.10) 1.81 (0.91) 0.97 (1.00) –0.13 –0.3 (–0.73, 0.13)
 Hygiene 1.69 (1.04) 1.19 (1.17) 1.75 (1.00) 0.96 (1.08) –0.23 –0.29 (–0.71, 0.14)
 Reach 1.89 (1.05) 1.46 (1.14) 1.95 (0.96) 1.04 (0.94) –0.42 –0.47 (–0.86, –0.08)
 Walking 1.62 (0.92) 1.11 (1.07) 1.52 (0.98) 0.76 (0.96) –0.35 –0.25 (–0.62, 0.12)
VAS
 Pain-global 53.51 (22.35) 28.19 (27.17) 61.4 (23.98) 22.33 (24.21) –5.86 –13.74 (–25.92, –1.56)
 Physician-global 61.35 (21.12) 25.49 (24.01) 69.63 (15.65) 21.75 (19.20) –3.74 –12.02 (–21.52, –2.51)
 Patient-global 56.27 (21.2) 29.38 (25.93) 60.28 (23.78) 21.29 (21.88) –8.09 –12.09 (–23.36, –0.83)
CHQ
 Global health 37.43 (28.06) 51.56 (21.98) 30.54 (25.66) 59.51 (26.57) 7.95 13.79 (0.34, 27.23)
 Physical function 34.98 (25.56) 56.16 (34.18) 35.04 (27.78) 69.02 (29.56) 12.86 16.75 (4.16, 29.34)
 Role/social limitation-physical 42.13 (30.21) 66.16 (35.47) 41.11 (33.37) 80.32 (26.59) 14.16 16.2 (0.23, 32.18)
 Role/social limitation-emotional 51.54 (34.24) 69.7 (34.5) 53.04 (34.20) 82.72 (25.49) 13.02 15.43 (–1.04, 31.91)
 Pain/discomfort 34.72 (19.93) 54.85 (28.63) 30.27 (21.12) 65.56 (26.10) 10.71 15.94 (4.41, 27.46)
 Behavior 64.00 (14.74) 61.36 (15.98) 63.72 (12.23) 69.12 (12.12) 7.76 7.20 (1.75, 12.64)
 Mental health 59.97 (15.65) 66.36 (17.91) 63.07 (19.12) 75.14 (17.58) 8.78 5.64 (–1.62, 12.9)
 Self-esteem 61.76 (20.91) 69.72 (23.7) 60.56 (20.92) 74.98 (18.81) 5.25 8.16 (–0.29, 16.61)
 General health 41.76 (13.85) 45.08 (13.48) 42.20 (14.43) 39.96 (14.97) –5.11 –4.59 (–10.19, 1.01)
 Parental emotional 38.43 (20.44) 52.78 (26.24) 39.44 (25.24) 62.38 (25.64) 9.61 10.16 (–0.76, 21.07)
 Parental time 57.72 (26.54) 69.02 (23.2) 60.59 (28.73) 72.99 (29.12) 3.97 2.08 (–10.83, 15)
 Family activity 50.67 (22.26) 65.03 (23.87) 59.72 (23.92) 75.02 (25.51) 10 3.60 (–6.21, 13.41)
 Family cohesion 75.97 (19.92) 69.24 (26.70) 70.33 (23.81) 75.56 (22.21) 6.31 10.66 (2.38, 18.94)
 CHQ-PhS 19.47 (12.85) 31.85 (17.02) 18.68 (13.84) 36.97 (13.99) 5.12 7.31 (1.13, 13.49)
 CHQ-PsS 40.64 (8.61) 43.57 (11.33) 41.38 (11.45) 48.44 (9.29) 4.87 4.85 (0.42, 9.27)
  1. *Data are mean (SD) unless otherwise specified. †ANOVA, p < 0.05. ‡Median (min, max). ANOVA, analysis of variance; CHAQ-DI, Childhood Health Assessment Questionnaire–Disability Index; CHQ, Child Health Questionnaire; HRQOL, health-related quality of life; PhS, physical summary; PsS, psychosocial summary; sJIA, systemic juvenile idiopathic arthritis; VAS visual analog scale