Table 1 (abstract A31). Change in HRQOL and Disability Within 3 Months of Starting Therapy in sJIA Patients*
Variable | Placebo n = 37 | Tocilizumab n = 75 | Difference | |||
|---|---|---|---|---|---|---|
Baseline | Week 12 | Baseline | Week 12 | At Week 12 | In Change From Baseline to Week 12‡ | |
CHAQ-DI | 1.66 (0.82) | 1.17 (0.99) | 1.74 (0.79) | 0.94 (0.77) | –0.23 | –0.31 (–0.62, 0.00) |
 Activity | 1.86 (1.00) | 1.30 (1.18) | 1.93 (0.99) | 1.19 (1.11) | –0.11 | –0.18 (–0.61, 0.25) |
 Rising | 1.51 (0.96) | 1.00 (1.08) | 1.55 (0.93) | 0.79 (0.92) | –0.21 | –0.25 (–0.67, 0.18) |
 Dressing and grooming | 1.84 (1.09) | 1.27 (1.19) | 1.91 (1.02) | 1.18 (1.00) | –0.09 | –0.16 (–0.54, 0.22) |
 Eating | 1.22 (1.18) | 0.89 (1.02) | 1.49 (1.06) | 0.64 (0.76) | –0.25 | –0.53 (–0.96, –0.09) |
 Grip | 1.65 (1.03) | 1.11 (1.10) | 1.81 (0.91) | 0.97 (1.00) | –0.13 | –0.3 (–0.73, 0.13) |
 Hygiene | 1.69 (1.04) | 1.19 (1.17) | 1.75 (1.00) | 0.96 (1.08) | –0.23 | –0.29 (–0.71, 0.14) |
 Reach | 1.89 (1.05) | 1.46 (1.14) | 1.95 (0.96) | 1.04 (0.94) | –0.42†| –0.47 (–0.86, –0.08) |
 Walking | 1.62 (0.92) | 1.11 (1.07) | 1.52 (0.98) | 0.76 (0.96) | –0.35 | –0.25 (–0.62, 0.12) |
VAS | ||||||
 Pain-global | 53.51 (22.35) | 28.19 (27.17) | 61.4 (23.98) | 22.33 (24.21) | –5.86 | –13.74 (–25.92, –1.56) |
 Physician-global | 61.35 (21.12) | 25.49 (24.01) | 69.63 (15.65) | 21.75 (19.20) | –3.74 | –12.02 (–21.52, –2.51) |
 Patient-global | 56.27 (21.2) | 29.38 (25.93) | 60.28 (23.78) | 21.29 (21.88) | –8.09 | –12.09 (–23.36, –0.83) |
CHQ | ||||||
 Global health | 37.43 (28.06) | 51.56 (21.98) | 30.54 (25.66) | 59.51 (26.57) | 7.95 | 13.79 (0.34, 27.23) |
 Physical function | 34.98 (25.56) | 56.16 (34.18) | 35.04 (27.78) | 69.02 (29.56) | 12.86 | 16.75 (4.16, 29.34) |
 Role/social limitation-physical | 42.13 (30.21) | 66.16 (35.47) | 41.11 (33.37) | 80.32 (26.59) | 14.16†| 16.2 (0.23, 32.18) |
 Role/social limitation-emotional | 51.54 (34.24) | 69.7 (34.5) | 53.04 (34.20) | 82.72 (25.49) | 13.02 | 15.43 (–1.04, 31.91) |
 Pain/discomfort | 34.72 (19.93) | 54.85 (28.63) | 30.27 (21.12) | 65.56 (26.10) | 10.71 | 15.94 (4.41, 27.46) |
 Behavior | 64.00 (14.74) | 61.36 (15.98) | 63.72 (12.23) | 69.12 (12.12) | 7.76†| 7.20 (1.75, 12.64) |
 Mental health | 59.97 (15.65) | 66.36 (17.91) | 63.07 (19.12) | 75.14 (17.58) | 8.78†| 5.64 (–1.62, 12.9) |
 Self-esteem | 61.76 (20.91) | 69.72 (23.7) | 60.56 (20.92) | 74.98 (18.81) | 5.25 | 8.16 (–0.29, 16.61) |
 General health | 41.76 (13.85) | 45.08 (13.48) | 42.20 (14.43) | 39.96 (14.97) | –5.11 | –4.59 (–10.19, 1.01) |
 Parental emotional | 38.43 (20.44) | 52.78 (26.24) | 39.44 (25.24) | 62.38 (25.64) | 9.61 | 10.16 (–0.76, 21.07) |
 Parental time | 57.72 (26.54) | 69.02 (23.2) | 60.59 (28.73) | 72.99 (29.12) | 3.97 | 2.08 (–10.83, 15) |
 Family activity | 50.67 (22.26) | 65.03 (23.87) | 59.72 (23.92) | 75.02 (25.51) | 10 | 3.60 (–6.21, 13.41) |
 Family cohesion | 75.97 (19.92) | 69.24 (26.70) | 70.33 (23.81) | 75.56 (22.21) | 6.31 | 10.66 (2.38, 18.94) |
 CHQ-PhS | 19.47 (12.85) | 31.85 (17.02) | 18.68 (13.84) | 36.97 (13.99) | 5.12 | 7.31 (1.13, 13.49) |
 CHQ-PsS | 40.64 (8.61) | 43.57 (11.33) | 41.38 (11.45) | 48.44 (9.29) | 4.87†| 4.85 (0.42, 9.27) |