Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)

Table 6 Association of AC cell grade and AC flare grade. Association of AC cell grade and AC flare grade in eyes with and without any structural complication

	All eyes				Eyes with at least one structural complications				Eyes with no structural complications
	AC cell grade				AC cell grade				AC cell grade
	0	0.5+	1+	2+/ 3+/ 4+	0	0.5+	1+	2+/ 3+/ 4+	0	0.5+	1+	2+/ 3+/ 4+
Baseline
AC flare grade: no flare	20 (66.7%)	5 (31.3%)	9 (17.0%)	7 (18.9%)	6 (46.2%)	2 (25.0%)	3 (10.3%)	3 (12.0%)	13 (81.3%)	3 (37.5%)	6 (25.0%)	4 (33.3%)
AC flare grade: any flare	10 (33.3%)	11 (68.8%)	44 (83.0%)	30 (81.1%)	7 (53.8%)	6 (75.0%)	26 (89.7%)	22 (88.0%)	3 (18.8%)	5 (62.5%)	18 (75.0%)	8 (66.7%)
3-months follow-up
AC flare grade: no flare	56 (83.6%)	6 (30.0%)	2 (14.3%)	2 (16.7%)	23 (82.1%)	4 (26.7%)	2 (18.2%)	2 (22.2%)	33 (84.6%)	2 (40.0%)	0 (0.0%)	0 (0.0%)
AC flare grade: any flare	11 (16.4%)	14 (70.0%)	12 (85.7%)	10 (83.3%)	5 (17.9%)	11 (73.3%)	9 (81.8%)	7 (77.8%)	6 (15.4%)	3 (60.0%)	3 (100.0%)	3 (100.0%)
6-months follow-up
AC flare grade: no flare	60 (87.0%)	1 (12.5%)	2 (33.3%)	0 (0.0%)	33 (82.5%)	1 (16.7%)	0 (0.0%)	0 (0.0%)	27 (93.1%)	0 (0.0%)	2 (66.7%)	0 (0.0%)
AC flare grade: any flare	9 (13.0%)	7 (87.5%)	4 (66.7%)	4 (100.0%)	7 (17.5%)	5 (83.3%)	3 (100.0%)	4 (100.0%)	2 (6.9%)	2 (100.0%)	1 (33.3%)	0 (0.0%)

All patients had active uveitis at baseline in at least one eye. Among all eyes that are affected with uveitis were 20 eyes inactive and had no flare at baseline

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