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Table 2 HLH/MAS Evidence-Based Guideline Diagnostic Evaluation

From: Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome

Potential Laboratory Evaluation
 CBC w/ diff
 Chem 10 (Na, K, Cl, CO2, BUN, Cr, Glucose, Ca, Mg, Phos)
 LFTs (AST, ALT, Tbili, Dbili)
 SPA Panel (IgG, IgM, IgA, C3, C4, CRP, Albumin, Protein)
 Coagulation Studies (PT, PTT, INR, Fibrinogen, D-dimer)
 Infectious Studies (EBV PCR, CMV PCR, Blood Culture)
 CD107a Mobilization/NK Cell Degranulation
 Soluble IL-2 Receptor
 Perforin/Granzyme Expression
 SAP/XIAP Expression (Males)
 Genetic Testing for FHL
Potential Radiologic Evaluation
 Chest X-ray
 Abdominal Ultrasound
  1. HLH hemophagocyticlymphohistiocytosis, MAS macrophage activation syndrome, SPA serum protein analysis panel, SAP SLAM-associated protein, XIAP X-linked inhibitor of apoptosis, FHL familial HLH