Pilot study comparing the childhood arthritis and rheumatology research alliance consensus treatment plans for induction therapy of juvenile proliferative lupus nephritis

Table 3 Induction corticosteroid exposure through week 24 by CTP*

Steroid	Primarily IV N = 15	Mixed Oral/IV N = 17	Primarily Oral N = 9
Oral prednisone or prednisolone
n patients with complete med log^a	14	14	9
Total gm	5.8 (4–8.4)	8.4 (6.2–9.2)	16.1 (7.7–17.7)
Total mg/kg	119 (72–142)	144 (94–160)	285 (114, 313)
Difference from expected, mg^b	− 108 (− 685, + 65)	+ 367 (− 692, + 1440)	− 338 (− 2650, + 1620)
IV methylprednisolone pulses
n patient with complete med logs^a	9	9	5
Total number of pulse doses	12 (6–14)	5 (3–8)	1 (0, 3)
Difference from expected, number of pulses^b	− 1 (− 7, 0)	−5 (− 5, 0)	0 (0, 0)^c

*All values presented as median (interquartile range), Abbreviations: CTP = Consensus treatment plan, IV = intravenous
^aPatients with incomplete steroid records were excluded from analysis
^bDifference from expected per CTP. A positive value (+) indicates more steroid was given than recommended per the CTP. A negative value (−) indicates less steroid was given per the CTP
^cIV pulses optional in the primarily oral CTP

ISSN: 1546-0096