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Table 1 (abstract P003). See text for description

From: Proceedings of the 25th European Paediatric Rheumatology Congress (PReS 2018)

  TCZ SC TCZ IV
<30 kg TCZ 162 mg Q2W n = 25 ≥30 kg TCZ 162 mg QW n = 26 <30 kg TCZ 12 mg/kg Q2W n = 46 ≥30 kg TCZ 8 mg/kg Q2W n = 43
Model-computed steady state PK parameters, median (range)
 Cmin,ss μg/mL 64.2 (16.6-135.9) 72.4 19.5-157.8) 65.9 (19.0-135.5) 70.7 (5.3-126.6)
 Cmax,ss μg/mL 126.6 (51.7-265.8) 89.8 (26.4-190.2) 274.4 (148.8-444.0) 253.0 (119.6-404.3)
 AUC2weeks,ss μg/mL×day 1298 (539-2792) 1154 (334-2370) 1734 (840-2712) 1631 (526-2779)