Table 1 (abstract P003). See text for description
From: Proceedings of the 25th European Paediatric Rheumatology Congress (PReS 2018)
| Â | TCZ SC | TCZ IV | ||
|---|---|---|---|---|
<30 kg TCZ 162 mg Q2W n = 25 | ≥30 kg TCZ 162 mg QW n = 26 | <30 kg TCZ 12 mg/kg Q2W n = 46 | ≥30 kg TCZ 8 mg/kg Q2W n = 43 | |
Model-computed steady state PK parameters, median (range) | ||||
 Cmin,ss μg/mL | 64.2 (16.6-135.9) | 72.4 19.5-157.8) | 65.9 (19.0-135.5) | 70.7 (5.3-126.6) |
 Cmax,ss μg/mL | 126.6 (51.7-265.8) | 89.8 (26.4-190.2) | 274.4 (148.8-444.0) | 253.0 (119.6-404.3) |
 AUC2weeks,ss μg/mL×day | 1298 (539-2792) | 1154 (334-2370) | 1734 (840-2712) | 1631 (526-2779) |