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Table 1 Patients’ characteristics according to the response to immunoglobulin infusion (N = 157)

From: Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions

  Resistant (N = 45)
N (%)
Responder (N = 112)
N (%)
p
Demographics
 Sex (M/F) 24/21 68/44 .36
Age 31 [24–40] 31 [27–36] .96
 < 12 months 13 (29) 22 (20) .39
 12–23 months 7 (16) 34 (30) .10
 ≥ 24 months 25 (55) 56 (50) .47
Clinics
 Fever length before Ig (days) 7 [5–8] 7 [6–8] .33
 Lymphadenopathy 18 (40) 47 (42) .72
 Rash 39 (87) 91 (81) .63
 Conjunctivitis 39 (87) 76 (68) .03
 Enanthem 33 (73) 89 (79) .67
 Modification of the extremities 18 (40) 51 (46) .47
 Fever length after Ig (hours) 60 [56–64] 24 [21–36] < 10 −10
Biology
 Neutrophils (%) 70 [66–74] 65 [62–69] .17
 Platelet count (G/L) 434,900 [375,140-494,680] 392,000 [361,860-421,420] .31
 Hemoglobin (g/dl) 10.4 [9.6–10.4] 10.7 [10.4–10.9] .60
 CRP (mg/L) 182 [159–207] 145 [131–160] .01
 ΔCRP (%) 41 [30–52] 61 [56–66] .0004
 ASAT (UI/L) 46 [39–54] 60 [44–74] .32
 ALAT (UI/L) 55 [42–69] 76 [54–98] .73
 Bilirubin (μmol/L) 10 [6–14] 12 [8–15] .91
 LDH (UI/L) 781 [611–950] 1442 [1073-1810] .62
 Albumin (g/L) 23 [21–25] 26 [25–27] .16
 Sodium (mmol/L) 135 [134–136] 135 [134–136] .44
Scores
 Kobayashi    1
  <  5 32 (78) 86 (78)  
  ≥ 5 9 (22) 25 (22)  
 Egami    .49
  < 3 32 (76) 88 (82)  
  ≥ 3 10 (24) 19 (18)  
 Sano    .50
  < 2 22 (67) 66 (73)  
  ≥ 2 11 (33) 24 (27)  
Treatments
 1st dose IV Ig 45 (100) 112 (100) 1
 2nd dose IV Ig 20 (40) 1 < 10 −8
 Corticosteroids 17 (39) 2 (2) < 10 −8
First echocardiogram results
 Normal 23 (51) 86 (77) .002
 Abnormal 22 (49) 26 (23) .002
 Coronary artery dilatation 11 (24) 13 (12) .05
 Pericardial effusion 7 (16) 8 (7) .13
 Perivascular brightness of the coronary arteries 4 (9) 3 (3) .10
 CAA 3 (7) 4 (4) .40
  Small (<  5 mm) 1 (2) 2 (2) 1
  Median (5–8 mm) 1 (2) 2 (2) 1
  Giant (>  8 mm) 1 (2) 0 .28
 Left ventricular dysfunction 4 (9) 2 (2) .05
 Mitral insufficiency 1 (2) 1 (1) .48
Abnormal late echocardiograms
 6 weeks 10 (22) 8 (7) .01
 Coronary artery dilatation 5 2  
 Pericardial effusion 1 0  
 Perivascular brightness of the coronary arteries 1 0  
 CAA 3 6  
  Small (<  5 mm) 0 4  
  Median (5–8 mm) 2 2  
  Giant (>  8 mm) 1 0  
Long-term 4 (9) 3 (3) .10
 Coronary artery dilatation 2 0  
 CAA 2 3  
  Small (<  5 mm) 1 3  
  Median (5–8 mm) 1 0  
  Giant (>  8 mm) 0 0  
  1. Sole p-values < 0.05 are in boldfaced and p-values = 0.05 are not in boldfaced