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Table 1 Literature Review: Summary of the Case Reports of Neonatal Kawasaki Disease (0–28 days of age)

From: Kawasaki Disease in the neonate: case report and literature review

Pt Ref Age at onsetb (days) Sex Fever duration (days) Rash Oral changes Extremity changesd Red eyes Cervical adenitis CAA c Other CRP (high/ WNL) IVIG res-ponse CA outcome (last F/U)
1 4 20 F 10 + + + + + DIC high + WNL (8mos)
2 6 10 M 5 + + + + + Apnea, seizures WNL + CAA (2.5 yrs)
3 7 8 F 9 + + + + + MR/AR high + WNL (6 wks)
4 8 16 F 13 + + + + + MR/TR high + N/A
5 9 20 F N/A + + + + MR/AR high + CAA (8 wks)
6 10 8 M > 9 + + + Myocardial ischemiaa high + CAA (9 wks)
7 5 22 F 4 + + high + WNL (3 mos)
8 11 18 M 6 + + + Pneumonitis WNL + WNL (6 wks)
9 11 16 M 7 + + + Cough, diarrhea high + WNL (11 yrs)
10 12 21 F 4 + + + Abdominal pain vomiting WNL + WNL (6 wks)
11 12 14 F 3 + + + Hyperemia WNL + WNL (6 mos)
12 12 16 M 4 + + + Hyperemia WNL + WNL
13 13 5 M 1 + CHF, MR/AR high + WNL(12mos)
14 14 1 M 0 + DIC, pericardial effusion N/A N/A WNL(12mos)
15 15 1 F 0 + MI, CA vasculitis N/A N/A death (day1)
16 PR 15 M 5 + + + Apnea pneumonitis WNL + WNL(12mos)
  1. CAA coronary artery abnormality, CRP C-reactive protein, IVIG intravenous immunoglobulin, DIC disseminated intravascular coagulation, CHF congestive heart failure, AR aortic regurgitation, TR tricuspid regurgitation, MI myocardial infarction, PR present report, N/A not available, MR mitral regurgitation, WNL within normal limits
  2. a Patient 6 underwent successful coronary thrombolysis
  3. b All patients were full term with the exception of patient #14 who was 35.5 weeks
  4. c Patients 2, 4, 5, 6, and 15 had CA aneurysms; patients 1, 2, 3, 13 and 14 had CA dilatations
  5. d Patients 1, 2, 3, 4, 5, 8, 9, 10, 11, 12 and 16 had distal edema; patients 1, 2, 3, 5, 6, 7, 8, 11 and 16 had desquamation