Fig. 2

ACR Scores. The number above each bar represents the number of patients at that dose. The four patients in the lowest dose group did not reach any ACR response at Month 1. The ACR Pediatric-30, −50, −70, and − 90 responses were defined as an improvement of at least 30% (or 50, 70, 90%, respectively) from baseline in at least 3 of the 6 signs and symptoms variables, with no more than 1 of the remaining variables worsening by > 30%. JIA signs and symptoms variables: physician’s global assessment of disease activity, CHAQ disability index score, CHAQ global assessment of well-being, number of joints with active arthritis, number of joints with limited range of motion, serum CRP or ESR