Fig. 3

CREM regulates T cell inflammation in arthritis. a Geometric (G)-Mean of CREM expression in PBMCs and SFMCs from JIA patients, two-tailed paired t-tests were used to calculate p-values. b PBMCs and SFMCs from JIA patients were transfected with control siRNA or with CREM siRNA and cultivated in RPMI for 24 h and percentages of CD161⁺IL-17⁺ in CD3⁺ T cells after restimulation with P/I in the presence of Brefeldin were determined, two-tailed paired t-tests were used to calculate p-values. c Graphic showing T cell mediated arthritis model. d Knee swelling of RAG^−/− mice after adoptive transfer of OT-II cells either from WT or from CREM^−/− mice, immunization with OVA and subsequent intraarticular injection of cationic ovalbumin. e Histological scores of arthritis-induced knee joints, Mann Whitney test were used to calculate p-values. f Hematoxylin and eosin staining of knee joint sections (arrow on the loft shows cellular infiltration, arrow on the right shows thickening of the synovial membrane)