Table 2 Outcome of studies evaluating local therapy for TMJ arthritis
From: Temporomandibular joint arthritis in juvenile idiopathic arthritis, now what?
Study | Subjective change | Physical exam change | Imaging change | Safety |
|---|---|---|---|---|
Arabshahi et al. [122] | Resolution of pain in 10/13 subjects | MIO increase of 4.8 mm | Improved active findings on MRI in > 67% of TMJs (14 subjects) | Transient Cushing syndrome in 2 subjects |
Ringold et al. [106] | Decreased incidence of one or more TMJ symptoms (60% to 28%) | MIO increase of 6.6 mm; decreased incidence of jaw deviation (40% to 16%) | CT: worsening changes in 10, no change in 3, and improvement in 2 subjects | Subcutaneous atrophy in 1 subject, IA calcification in two subjects |
Weiss et al. [14] | ND | Improved MIO in 9/16 abnormal at baseline | Decreased MRI findings of active arthritis in 5/6 | ND |
Parra et al. [123]1 | “Good” response in 80/99 encounters, “Partial” response in 10, and “Poor” response in 9 | ND | ND | Skin atrophy in 1 subject |
Mino et al. [67] | Resolution of pain in 11/15 (73%) with pain at baseline | Improved MIO of 5 mm among the 18 patients with decreased MIO at baseline | ND | Transient painless erythema in 24/28 (86%); metallic taste in one subject |
Habibi et al. [124] | Improved pain in 17/17 subjects and improved chewing dysfunction in 5/7 subjects | Improved jaw deviation in 13/14 subjects | ND | Scar in one subject |
Stoll et al. [125] | ND | Increased MIO by 2.7 mm | Of 62 TMJs: 24 improved, 30 stable, 8 worse | One subject each with localized swelling, fever x two weeks, and hypopigmentation |
Stoll et al. [56] | ND | No change in MIO | No improvement overall by MRI; resolution of inflammation in six TMJs | No AEs |
Olsen-Bergem et al. [64] | Improved pain at rest and with palpation | Increased lateral excursion of 3.7 mm (Triamcinolone group) | ND | ND |
Olsen-Bergem et al. [64] | Improved pain at rest and with palpation | Increased lateral excursion of 4.6 mm (arthrocentesis alone group) | ND | ND |
Lochbuhler et al. [52]2 | ND | ND | Improved inflammatory grade of MRI | Decreased growth of mandibular ramus |
Stoll et al. [55] | ND | No change in MIO | Worsening of active and chronic MRI findings | ND |
Stoustrup et al. [126] | Improved short-term pain frequency and intensity | No significant changes in MIO, laterotrusion, or protrusion | ND | ND |
Kinard et al. [65] | Decreased pain | Improved MIO | ND | Transient subcutaneous atrophy |
Resnick et al. [127] | Decreased pain | Improved MIO of 5.8 mm | Decreased ER of 1.06 | ND |
Resnick et al. [128] | Resolution of pain in 34/37 (92%) | Improved MIO of 5.0 mm (anatomic) or 5.1 mm (image) | Decreased ER of 1.16 (anatomic) or 0.96 (image) | ND |
Antonarakis et al. [66] | TA: Decreased VAS 2.6 L: Decreased VAS 1 | TA: Improved MIO of 2.3 mm L: Improved MIO of 1.4 mm | TA: Improved in 18 / 42 TMJs L: Improved in 5/16 | ND |