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Table 3 Proteins identified by iTRAQ in control group, LCWMP and LCBMP

From: Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?

 

Relative Abundance

p ANOVA Test (post hoc Bonferroni)

Function

Identified Proteins

Control

LCWMP

LCBMP

Apolipoprotein A-I

1

0.8

2.1

< 0.0001*

Anti-inflamtatory protein; reverse cholesterol transport

α-2-macroglobulin

1

0.8

1.3

< 0.0001*

Anti-inflamtatory protein; Protease inhibition

α −1-antitripsin

1

0.7

1.5

0.0084*

Anti-inflamtatory protein; Protease inhibition

Apolipoprotein E

1

0.9

2.2

0.0086*

Anti-inflamtatory protein; Fat-soluble vitamins and cholesterol transport

Ceruloplasmin

1

0.9

1.6

0.00058*

Anti-inflamtatory protein; Copper and iron transport

Complement C3

1

0.8

1.3

0.0014*

Anti-inflamtatory protein; Complement system activation

Fibrinogen-α chain

1

0.7

0.9

0.0047*

Pro-inflamtatory protein;Coagulation and fibrinolysis

Haptoglobin

1

1.3

2.5

< 0.0001*

Anti-inflamtatory protein; Iron metabolin - antioxidant

Hemopexina

1

0.9

1.7

0.0010*

Anti-inflamtatory protein; Iron metabolin - antioxidant

Serum transferrin

1

0.8

1.7

< 0.0001*

Anti-inflamtatory protein; Iron metabolin - antioxidant

  1. *p < 0.005
  2. LCWMP Lupus Cluster with the Best Metabolic Profile, LCBMP Lupus Cluster with the Worst Metabolic Profile
  3. Abundances were compared between three groups
  4. by ANOVA, post hoc Bonferroni
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Pediatric Rheumatology

ISSN: 1546-0096