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Table 3 Proteins identified by iTRAQ in control group, LCWMP and LCBMP

From: Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?

  Relative Abundance p ANOVA Test (post hoc Bonferroni) Function
Identified Proteins Control LCWMP LCBMP
Apolipoprotein A-I 1 0.8 2.1 < 0.0001* Anti-inflamtatory protein; reverse cholesterol transport
α-2-macroglobulin 1 0.8 1.3 < 0.0001* Anti-inflamtatory protein; Protease inhibition
α −1-antitripsin 1 0.7 1.5 0.0084* Anti-inflamtatory protein; Protease inhibition
Apolipoprotein E 1 0.9 2.2 0.0086* Anti-inflamtatory protein; Fat-soluble vitamins and cholesterol transport
Ceruloplasmin 1 0.9 1.6 0.00058* Anti-inflamtatory protein; Copper and iron transport
Complement C3 1 0.8 1.3 0.0014* Anti-inflamtatory protein; Complement system activation
Fibrinogen-α chain 1 0.7 0.9 0.0047* Pro-inflamtatory protein;Coagulation and fibrinolysis
Haptoglobin 1 1.3 2.5 < 0.0001* Anti-inflamtatory protein; Iron metabolin - antioxidant
Hemopexina 1 0.9 1.7 0.0010* Anti-inflamtatory protein; Iron metabolin - antioxidant
Serum transferrin 1 0.8 1.7 < 0.0001* Anti-inflamtatory protein; Iron metabolin - antioxidant
  1. *p < 0.005
  2. LCWMP Lupus Cluster with the Best Metabolic Profile, LCBMP Lupus Cluster with the Worst Metabolic Profile
  3. Abundances were compared between three groups
  4. by ANOVA, post hoc Bonferroni