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Table 1 Correlation of demographic features and disease characteristics with response to NSAID monotherapy

From: Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis

  Responded to NSAID monotherapy Failed NSAID monotherapy Did not receive a trial of NSAID monotherapy p-value comparing trial (columns 1 and 2) vs no trial (column 3) p-value comparing responded to trial (column 1) vs. failed trial (column 2)
Patients 13 38 36   
Demographic features
 Male, n (%) 7 (54%) 15 (39%) 17 (47%) 0.71 0.52
 Age at presentation, mean (SD) 4.8 (3.6) 7.1 (4.7) 6.1 (4.6) 0.68 0.10*
 Age ≤ 8 years at presentation, n (%) 11 (85%) 21 (55%) 27 (75%) 0.23 0.10*
Disease characteristics
 Initial joint count, mean (SD) 1.8 (1.6) 5.7 (9.0) 4.7 (6.3) 0.98 0.01**
 Joint count ≤5, n (%) 13 (100%) 29 (76%) 29 (81%) 0.83 0.09*
 Characteristic rash, n (%) 13 (100%) 34 (89%) 33 (92%) 0.93 0.56
 Generalized lymphadenopathy, n (%) 2 (15%) 6 (16%) 9 (25%) 0.28 1.00
 Hepatosplenomegaly, n (%) 2 (15%) 7 (18%) 5 (14%) 0.64 1.00
 Serositis, n (%) 0 (0%) 1 (3%) 8 (22%) 0.003** 1.00
 CRP ≤13 mg/dL*, n (%) 12 (92%) 26 (68%) 17 (59%) 0.14* 0.14*
 MAS at diagnosis, n (%) 0 (0%) 2 (5%) 7 (19%) 0.03** 1.00
 MAS ever, n (%) 0 (0%) 6 (16%) 11 (31%) 0.03** 0.32
 WBC (K/μL), mean (SD) 16.7 (±7.0) 16.4 (±7.0) 19.6 (±10.1) 0.15 0.89
 Hg (g/dL), mean (SD) 10.4 (±0.9) 10.1 (±1.5) 9.9 (±1.6) 0.45 0.47
 Platelets (K/μL), mean (SD) 492 (±193) 486 (±222) 519 (±248) 0.57 0.93
 ESR (mm), mean (SD) 80 (±26) 77 (±26) 75 (±31) 0.69 0.81
 Ferritin (ng/mL), mean (SD) 410 (±722) 3042 (±4813) 3060 (±3777) 0.55 0.07*
Outcomes
 Days to clinically inactive disease, median (range) 49 (28-356) 764 (13-3806) 267 (0-2716) 0.60 0.0001**
 Days to medication escalation, median (range) n/a 32 (2-146) n/a n/a n/a
 Days to first follow-up, median (range) 48 (28-252) 21 (6-327) 27 (9-188) 0.33 0.004**
 Days of disease duration prior to diagnosis, median (range) 55 (26-492) 46 (14-484) 81 (11-848) 0.25 0.60
 Days of total follow-up, median (range) 1000 (154-3164) 1693 (0-4229) 956 (188-4678) 0.45 0.37
  1. P-values below 0.25 have one asterisk (*) and were considered trending (based on Wald test from logistic regression). P-values below 0.05 have two asterisks (**) and were considered statistically significant. All p-values below 0.25 are bolded