Table 3 Summary of published reports describing pediatric patients with JIA receiving influenza vaccine
Article | Vaccination season Vaccine type | Methodology antibody response | Number of JIA patients | Number of controls | Number of JIA patients on biological therapy | Adverse events (AE) | Efficacy (seroprotection) according to group and vaccine type | Time post-vaccination |
|---|---|---|---|---|---|---|---|---|
Toplak et al. [18]. 2012 Slovenia | 2008/2009 A/(H1N1)pdm, H3N2,B | Virus neutralization test | 31 | 14 | anti-TNFα 4 | Short-term AE: JIA 35% Control 36% | JIA 100%H1N1 100% H3N2 84%B | 1 month |
Pain at injection site: JIA 32% Control 21% | anti-TNFα 75%H1N1 75%H3N2 10% B | |||||||
Malaise and headache: JIA 3% Control 14% No severe AE | Control 100% H1N1 100%H3N2 78%B | |||||||
Malleson et al. [6]. 1993 Canada | 1991/1992-2008/2009 A/(H1N1)pdm, H3N2,B | HAI | 26 | 13 | 0 | Soreness and redness at injection site: JIA 69% and 15% Control 69% and 8% | JIA 100% H1N1 97% H3N2 97% B | 4 - 6 week |
Fever and feeling unwell: JIA 19% and 46% Control 8% and 26% No severe AE | Control 90% H1N1 90% H3N2 90% B | |||||||
Dell’ Era et al. [25]. 2012 Italy | 2010/2011-2008/2009 A/(H1N1)pdm, H3N2,B | HAI | 60 | 30 | Etanercept 30 | Local AE: JIA with DMARD 43.3% JIA with Etanercept 36.7% Control 40% Systemic AE: JIA with DMARD 30% JIA with Etanercept 26.7% Control 26.7% Severe AE: JIA with DMARD 3.3% JIA with Etanercept 3.3% | JIA with DMARD 100% H1N1 100% H3N2 83.3% B JIA with Etanercept 100% H1N1 100% H3N2 30% B Control 100% H1N1 100% H3N2 93,3% B | 1 month |
Aikawa et al. [26]. 2013 Brazil | 2009 A/(H1N1)pdm | HAI | 95 | 91 | anti-TNFα 16 | Local pain: JIA 21.1% Control 23.1% | JIA 88.4% H1N1 anti-TNFα 100% H1N1 Control 95.6% H1N1 | 3 weeks |
No severe AE | ||||||||
Shinoki et al. [9]. 2012 Japan | 2007/2008 A/(H1N1)pdm, H3N2,B | HAI | 27 | 17 | Tocilizumab 27 | Local AE: JIA14.8% Control 0% | JIA 88.9% H1N1 85.2% H3N2 40.7% B | 4 -7 weeks |
No severe AE | Control 76.5% H1N1 100% H3N2 35.3% B | |||||||
Miraglia et al. [5]. 2011 Brazil | 2009 A/(H1N1)pdm | HAI | 83 | - | Not specified | 1.3% redness, 20% malaise JIA | JIA 85.5% H1N1 | 3 weeks |
No severe AE | ||||||||
Carvalho et al. [8]. 2013 Brazil | 2008 A/(H1N1)pdm, H3N2,B | HAI | 44 | 10 | anti-TNFα 5 | Local pain JIA 13.6% Control 10% Other local change JIA4.5% Control 10% | JIA 100% H1N1 93% H3N2 95% B Anti TNFα 60% H1N1 100% H3N2 80% B Control 100% H1N1 80% H3N2 100 B | 30-40 days |