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Table 4 HLA-G genotype, allele and haplotype frequencies in patient sub groups

From: “HLA-G 3′UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population”

  Healthy Siblings (126) n (%) RF 10 n (%) OR (95% CI) pc MVL 67 n (%) OR (95% CI) pc CVL 22 n (%) OR (95% CI) pc
14 bp Ins/Del
Genotypes
Ins/Ins 27 (21.4) 2 (20.0) 0.92 (0.18-4.57) 0.7680 9 (13.4) 0.57 (0.25-1.29) 0.2446 5 (22.7) 1.08 (0.36-3.19) 0.8854
Del/Del 36 (28.6) 2 (20.0) 0.62 (0.13-3.09) 0.8294 24 (35.8) 1.39 (0.74-2.62) 0.3829 9 (40.9) 1.73 (0.68-4.40) 0.3630
Ins/Del 63 (50.0) 6 (60.0) 1.5 (0.40-5.57) 0.7792 34 (50.8) 1.03 (0.57-1.86) 0.9581 8 (36.4) 0.57 (0.22-1.46) 0.3421
Alleles
Ins 117 (46.4) 10 (50.0) 1.15 (0.46-2.86) 0.9399 52 (38.8) 0.73 (0.48-1.12) 0.1837 18 (40.9) 0.80 (0.42-1.53) 0.6070
Del 135 (53.6) 10 (50.0) 0.87 (0.35-2.15) 0.9399 82 (61.2) 1.37 (0.89- 2.09) 0.1837 26 (59.1) 1.25 (0.65-2.40) 0.6070
+3142 C/G
Genotypes
C/C 6 (4.8) 0 0 0.9250 7 (10.5) 2.33 (0.75-7.25) 0.2306 5 (22.7) 5.88 (1.62-21.39) 0.0116 a
G/G 66 (52.4) 4 (40.0) 0.61 (0.16-2.25) 0.6705 34 (50.7) 0.94 (0.52-1.69) 0.9481 10 (45.5) 0.76 (0.30-1.89) 0.7124
C/G 54 (42.8) 6 (60.0) 2.0 (0.54-7.44) 0.4714 26 (38.8) 0.84 (0.46-1.55) 0.6962 7 (31.8) 0.62 (0.24-1.63) 0.4618
Alleles
C 66 (26.2) 6 (30.0) 1.21 (0.44-3.27) 0.9136 40 (29.9) 1.20 (0.75-1.90) 0.5174 17 (38.6) 1.78 (0.91-3.46) 0.1300
G 186 (73.8) 14 (70.0) 0.83 (0.30-2.24) 0.9136 94 (70.1) 0.83 (0.52-1.33) 0.5174 27 (61.4) 0.56 (0.29-1.10) 0.1300
Haplotypes
Ins/G 117 (46.4) 10 (50.0) 1.15 (0.46-2.86) 0.9399 52 (38.8) 0.73 (0.48-1.12) 0.1837 18 (40.9) 0.80 (0.42-1.53) 0.6070
Del/G 69 (27.4) 4 (20.0) 0.66 (0.21-2.05) 0.6491 42 (31.3) 1.21 (0.76-1.91) 0.4835 9 (20.5) 0.68 (0.31-1.49) 0.4372
Del/C 66 (26.2) 6 (30.0) 1.21 (0.44-3.27) 0.9136 40 (29.9) 1.19 (0.75-1.91) 0.5174 17 (38.6) 1.78 (0.91-3.46) 0.1300
  1. RF- Rheumatic Fever, MVL-Mitral Valvular Lesions, CVL-Combined Valvular Lesions, CI-confidence interval, OR-odds ratio, pc-Yates corrected p value
  2. a - χ 2 = 6.3692, Fisher Exact P (Pf) = 0.0117
  3. Bold - significant p value (<0.05)
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Pediatric Rheumatology

ISSN: 1546-0096