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Table 4 HLA-G genotype, allele and haplotype frequencies in patient sub groups

From: “HLA-G 3′UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population”

 

Healthy Siblings (126) n (%)

RF 10 n (%)

OR (95% CI)

pc

MVL 67 n (%)

OR (95% CI)

pc

CVL 22 n (%)

OR (95% CI)

pc

14 bp Ins/Del

Genotypes

Ins/Ins

27 (21.4)

2 (20.0)

0.92 (0.18-4.57)

0.7680

9 (13.4)

0.57 (0.25-1.29)

0.2446

5 (22.7)

1.08 (0.36-3.19)

0.8854

Del/Del

36 (28.6)

2 (20.0)

0.62 (0.13-3.09)

0.8294

24 (35.8)

1.39 (0.74-2.62)

0.3829

9 (40.9)

1.73 (0.68-4.40)

0.3630

Ins/Del

63 (50.0)

6 (60.0)

1.5 (0.40-5.57)

0.7792

34 (50.8)

1.03 (0.57-1.86)

0.9581

8 (36.4)

0.57 (0.22-1.46)

0.3421

Alleles

Ins

117 (46.4)

10 (50.0)

1.15 (0.46-2.86)

0.9399

52 (38.8)

0.73 (0.48-1.12)

0.1837

18 (40.9)

0.80 (0.42-1.53)

0.6070

Del

135 (53.6)

10 (50.0)

0.87 (0.35-2.15)

0.9399

82 (61.2)

1.37 (0.89- 2.09)

0.1837

26 (59.1)

1.25 (0.65-2.40)

0.6070

+3142 C/G

Genotypes

C/C

6 (4.8)

0

0

0.9250

7 (10.5)

2.33 (0.75-7.25)

0.2306

5 (22.7)

5.88 (1.62-21.39)

0.0116 a

G/G

66 (52.4)

4 (40.0)

0.61 (0.16-2.25)

0.6705

34 (50.7)

0.94 (0.52-1.69)

0.9481

10 (45.5)

0.76 (0.30-1.89)

0.7124

C/G

54 (42.8)

6 (60.0)

2.0 (0.54-7.44)

0.4714

26 (38.8)

0.84 (0.46-1.55)

0.6962

7 (31.8)

0.62 (0.24-1.63)

0.4618

Alleles

C

66 (26.2)

6 (30.0)

1.21 (0.44-3.27)

0.9136

40 (29.9)

1.20 (0.75-1.90)

0.5174

17 (38.6)

1.78 (0.91-3.46)

0.1300

G

186 (73.8)

14 (70.0)

0.83 (0.30-2.24)

0.9136

94 (70.1)

0.83 (0.52-1.33)

0.5174

27 (61.4)

0.56 (0.29-1.10)

0.1300

Haplotypes

Ins/G

117 (46.4)

10 (50.0)

1.15 (0.46-2.86)

0.9399

52 (38.8)

0.73 (0.48-1.12)

0.1837

18 (40.9)

0.80 (0.42-1.53)

0.6070

Del/G

69 (27.4)

4 (20.0)

0.66 (0.21-2.05)

0.6491

42 (31.3)

1.21 (0.76-1.91)

0.4835

9 (20.5)

0.68 (0.31-1.49)

0.4372

Del/C

66 (26.2)

6 (30.0)

1.21 (0.44-3.27)

0.9136

40 (29.9)

1.19 (0.75-1.91)

0.5174

17 (38.6)

1.78 (0.91-3.46)

0.1300

  1. RF- Rheumatic Fever, MVL-Mitral Valvular Lesions, CVL-Combined Valvular Lesions, CI-confidence interval, OR-odds ratio, pc-Yates corrected p value
  2. a - χ 2 = 6.3692, Fisher Exact P (Pf) = 0.0117
  3. Bold - significant p value (<0.05)
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Pediatric Rheumatology

ISSN: 1546-0096