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Table 4 Toxicity in the three treatment arms

From: A comparison of three treatment strategies in recent onset non-systemic Juvenile Idiopathic Arthritis: initial 3-months results of the BeSt for Kids-study

Treatment arm Arm 1
Sequential monotherapy
MTX or SSZ
n = 32
Arm 2
Combo MTX + 6 wks prednisone
n = 32
Arm 3
Combo
MTX + etanercept
n = 30
Total number of AEs 33 46 39
Number of SAEs 2 1 0
Cardiovascular 0 0 1
Pulmonary 1 2 0
Gastrointestinal 7 14 9
 -Nausea 3 8 6
 -Vomiting 0 3 1
 -Diarrhoea 0 1 1
 -Rectal Blood loss 1 0 0
 -Liver enzyme abnormality 3 2 2
Neurologic 4 3 2
 -Headache 2 0 1
 -Sleeping disturbances 1 2 0
 -Behavioral problems 1 1 1
Leukopenia 5 1 1
Skin/mucosal membranes 3 4 3
Infectious 8 6 13
 -Upper respiratory tract infection 1 1 8
 -Gastro-enteritis 0 1 1
 -Skin/mucosal infection 1 1 2
 -Fever 2 1 1
 -Infectious other 1 2 1
General malaise/fatigue 3 5 1
Other 0 3 2