TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population

Table 4 Haplotype analysis of RA and JIA cases and the healthy controls in the TLR4 genes

NO.	haplotype^a	RA		OR [95CI%], P ^b	JIA		OR [95CI%], P ^b
NO.	haplotype^a	Control (freq.)	Case (freq.)	OR [95CI%], P ^b	Control (freq.)	Case (freq.)	OR [95CI%], P ^b
H1	T A C G G G	0.47	0.43	1.03 [0.99–1.17],0.29	0.45	0.42	0.72 [0.52–1.01],0.06
H2	T A C G G C	0.06	0.12	1.07 [0.83–1.33],0.07	0.06	0.10	1.74 [0.95–3.21],0.07
H3	T A C G C G	0.11	0.09	0.54 [0.22–1.11],0.13	0.10	0.07	0.66 [0.36–1.23],0.19
H4	T G T C C G	0.02	0.08	1.13 [0.77–1.26],0.001	0.04	0.08	2.06 [1.01–4.21] 0.04
H5	T A C C C C	0.003	0.01	1.09 [0.76–1.45],0.06	0.003	0.006	1.75 [0.11–2.86],0.39
H6	C A C G G G	0.06	0.06	1.01 [0.99–1.03],0.89	0.04	0.06	1.54 [0.72–3.31],0.26
H7	C A C G C G	0.01	0.02	1.10 [0.98–1.24],0.57	0.02	0.02	0.87 [0.26–2.93],0.78
H8	C A C G C C	0.003	0.001	0.86 [0.63–1.05],0.69	0.002	0.003	1.74 [0.11–2.04],0.54
H9	C A C C G G	0.14	0.11	0.98 [0.97–0.99],0.07	0.15	0.11	0.70 [0.42–1.16],0.17
H10	C G T C C G	0.03	0.13	1.15 [1.02–1.56],0.001	0.03	0.07	2.47 [1.11–5.49],0.02

Abbreviation: SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence intervals; −, not calculated, RA Rheumatoid arthritis, JIA juvenile idiopathic arthritis, Freq frequency
^aHaplotype structure of TLR4 for RA and JIA were rs4986790, rs4986791, rs10759932,rs41426344, rs11536889, rs7873784
^b P value were calculated using Fisher’s exact test

ISSN: 1546-0096