Table 3 Distribution of the genotypes of TLR4 gene polymorphisms in RA and JIA cases and controls
SNPs | Genotype | Control no. | RA no. | OR [95%CI] | p a | p b adj | Control no. | JIA no. | OR [95%CI] | p a | p b adj |
|---|---|---|---|---|---|---|---|---|---|---|---|
rs10759932 (C) | TT | 844 | 498 | 0.87 [0.74–1.01] | 0.07 | – | 204 | 125 | 1.16 [0.83–1.62] | 0.39 | – |
|  | CT | 696 | 466 | 1.09 [0.94–1.28] | 0.24 | – | 151 | 73 | 0.76 [0.54–1.08] | 0.13 | – |
|  | CC | 143 | 108 | 1.21 [0.93–1.57] | 0.15 | – | 23 | 19 | 1.48 [0.79–2.79] | 0.22 | – |
rs4986790 (G) | AA | 1671 | 1029 | 0.28 [0.17–0.49] | <0.001 | <0.001 | 372 | 208 | 0.37 [0.13–1.06] | 0.06 | – |
|  | GA | 21 | 45 | 3.47 [2.06–5.87] | <0.001 | <0.001 | 6 | 9 | 2.68 [0.94–7.64] | 0.06 | – |
|  | GG | 0 | 0 | – | – | – | 0 | 0 | – | – | – |
rs4986791 (T) | CC | 1590 | 986 | 0.72 [0.53–0.96] | 0. 03 | 0.09 | 399 | 186 | 0.58 [0.35–0.97] | 0.04 | 0.12 |
|  | CT | 100 | 85 | 1.37 [1.01–1.84] | 0.04 | 0.12 | 39 | 30 | 1.65 [0.99–2.73] | 0.05 | – |
|  | TT | 2 | 3 | – | – | – | 0 | 1 | – | – | – |
rs41426344 (C) | GG | 1287 | 615 | 0.42 [0.36–0.49] | <0.001 | <0.001 | 280 | 127 | 0.49 [0.35–0.70] | <0.001 | <0.001 |
|  | GC | 369 | 378 | 1.94 [1.64–2.31] | <0.001 | <0.001 | 91 | 72 | 1.57 [1.08–2.26] | 0.02 | 0.06 |
|  | CC | 36 | 81 | 3.75 [2.51–5.6] | <0.001 | <0.001 | 7 | 18 | 4.79 [1.97–11.67] | 0.0002 | 0.0006 |
rs11536889 (C) | GG | 1113 | 647 | 0.79 [0.67–0.92] | 0.003 | 0.009 | 242 | 133 | 0.89 [0.63–1.26] | 0.51 | – |
|  | GC | 518 | 372 | 1.20 [1.02–1.41] | 0.03 | 0.09 | 125 | 70 | 0.96 [0.67–1.37] | 0.84 | – |
|  | CC | 60 | 54 | 1.44 [0.99–2.09] | 0.06 | – | 11 | 14 | 2.3 [1.02–5.16] | 0.04 | 0.12 |
rs7873784 (C) | GG | 1308 | 790 | 0.81 [0.68–0.97] | 0.02 | 0.06 | 278 | 165 | 1.14 [0.78–1.68] | 0.50 | – |
|  | GC | 358 | 268 | 1.24 [1.03–1.48] | 0.02 | 0.06 | 96 | 48 | 0.83 [0.56–1.23] | 0.37 | – |
|  | CC | 25 | 16 | 1.01 [0.54–1.89] | 1.00 | – | 4 | 4 | 1.76 [0.43–7.09] | – | – |