Lipoprotein cholesterol fractions are related to markers of inflammation in children and adolescents with juvenile idiopathic arthritis: a cross sectional study

Table 4 Associations between cholesterol fractions and disease characteristics, fatness, and physical activity P values with correlation coefficients, and 95 % confidence interval in brackets

Patients	TC mmol/l	HDLc mmol/l	LDLc mmol/l
Gender T-test	0.05	0.19	0.12
Tanner stage (≤4 or = 5) T-test	0.87	0.51	0.85
Subgroup of JIA ANOVA	0.05	0.85	0.09
Treatment ^a ANOVA	0.83	0.68	0.98
Disease duration Bivariate correlation	0.93	0.19	0.84
Primary endpoints:
MRP 8/14 Bivariate correlation, p value Pearson correlation coefficient, r 95 % confidence interval	0.20	<0.0005* −0.343 (−0.474 to −0.201)	0.92
CRP Bivariate correlation, p value Pearson correlation coefficient, r 95 % confidence interval	0.83	0.043 −0.167 (−0.319 to–0.015)	0.63
JADAS 27 ^b Nonparametric correlation	0.66	0.72	0.92
Waist-to-height ratio Bivariate correlation, p value Pearson correlation coefficient r 95 % confidence interval	0.824	0.018 −0.187 (−0.345 to–0.033)	0.199
BMI SDS Bivariate correlation	0.15	0.13	0.49
Counts per minute (cpm) (133 patients) Bivariate correlation	0.23	0.25	0.33
Sedentary time (minutes/day) (133 patients) Bivariate correlation	0.23	0.61	0.11
High activity (minutes/day) (133 patients) Bivariate correlation	0.15	0.21	0.17

TC total cholesterol, HDLc high density fraction of cholesterol, LDLc low density fraction of cholesterol
*Significance (p) is given as two-tailed and α selected after Bonferoni correction as 0.004 (12 independent tests)
^aTreatment: Methotrexate versus TNF-α inhibitor versus IL-6 receptor inhibitor versus T-cell co-stimulation inhibitor CTLA-4-Ig
^bJADAS27 (0–57): a composite score of: number of joints with active disease (max 27), Physician global VAS, patient/parent global VAS and truncated ESR (tESR)
All parametric bivariate correlations have been performed after log10 transformation

ISSN: 1546-0096