Table 3 Clinical correlates with trans-iliac histomorphometry
From: Bone histomorphometric changes in children with rheumatic disorders on chronic glucocorticoids
Clinical variable | Structural parameters | Formation parameters | ||
|---|---|---|---|---|
| Â | Bone volume (BV/TV) a | Trabecular Thickness (Tb. Sp) a | Osteoid thickness (O.Th) a | Osteoblast surface (Ob.S/BS) a |
Average glucocorticoid dose (mg/m2/day) | −0.61 ( p  = 0.01) | −0.66 ( p  < 0.01) | −0.61 ( p  = 0.01) | −0.88 ( p  < 0.01) |
Cumulative glucocorticoid dose (mg/m2) | −0.32 (p = NS) | −0.25 (p = NS) | −0.39 (p = NS) | −0.89 ( p  < 0.01) |
Glucocorticoid duration | −0.11 (p = NS) | −0.17 (p = NS) | −0.30 (p = NS) | −0.52 ( p  = 0.04) |
Height Z score | 0.35 (p = NS) | 0.50 ( p  = 0.04) | 0.43 (p = NS) | 0.70 ( p  < 0.01) |
BMI Z score | −0.33 (p = NS) | −0.29 (p = NS) | −0.19 (p = NS) | −0.70 ( p  < 0.01) |
Number of vertebral compression fractures | −0.51 ( p  = 0.04) | −0.23 (p = NS) | −0.43 (p = NS) | −0.87 ( p  < 0.01) |
Lumbar spine areal BMD Z score | 0.19 (p = NS) | 0.26 (p = NS) | 0.20 (p = NS) | 0.40 (p = NS) |
Lumbar spine BMAD Z score | 0.13 (p = NS) | 0.05 (p = NS) | −0.10 (p = NS) | 0.25 (p = NS) |