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Table 3 Clinical correlates with trans-iliac histomorphometry

From: Bone histomorphometric changes in children with rheumatic disorders on chronic glucocorticoids

Clinical variable Structural parameters Formation parameters
  Bone volume (BV/TV) a Trabecular Thickness
(Tb. Sp) a
Osteoid thickness
(O.Th) a
Osteoblast surface (Ob.S/BS) a
Average glucocorticoid dose (mg/m2/day) −0.61 ( p= 0.01) −0.66 ( p< 0.01) −0.61 ( p= 0.01) −0.88 ( p< 0.01)
Cumulative glucocorticoid dose (mg/m2) −0.32 (p = NS) −0.25 (p = NS) −0.39 (p = NS) −0.89 ( p< 0.01)
Glucocorticoid duration −0.11 (p = NS) −0.17 (p = NS) −0.30 (p = NS) −0.52 ( p= 0.04)
Height Z score 0.35 (p = NS) 0.50 ( p= 0.04) 0.43 (p = NS) 0.70 ( p< 0.01)
BMI Z score −0.33 (p = NS) −0.29 (p = NS) −0.19 (p = NS) −0.70 ( p< 0.01)
Number of vertebral compression fractures −0.51 ( p= 0.04) −0.23 (p = NS) −0.43 (p = NS) −0.87 ( p< 0.01)
Lumbar spine areal BMD Z score 0.19 (p = NS) 0.26 (p = NS) 0.20 (p = NS) 0.40 (p = NS)
Lumbar spine BMAD Z score 0.13 (p = NS) 0.05 (p = NS) −0.10 (p = NS) 0.25 (p = NS)
  1. Data are Pearson’s correlation r (p value). All significant results (p < 0.05) are highlighted in bold. NS = not significant
  2. aHistomorphometry results were converted to percentiles compared to published age matched normative data prior to analysis