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Fig. 2 | Pediatric Rheumatology

Fig. 2

From: Biologic agents in juvenile spondyloarthropathies

Fig. 2

Interactions between genes products and cytokines. References: ERAP1: endoplasmic reticulum aminopeptidasa. UPR : unfolded protein. The misfolding HLA-B27 mechanism in the endoplasmic reticulum, up regulate the UPR. Higher levels of UPR generates an inappropriate genes activation that perpetuate the inflammatory state

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Pediatric Rheumatology

ISSN: 1546-0096