Table 4 Comparison of cases with different JIA categories with autoimmune disorders among first-degree relatives
From: Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry
Family history of disease | JIA categorya | P-valueb | |||||||
|---|---|---|---|---|---|---|---|---|---|
(N = 4441) | |||||||||
Systemic | Poly RF(−) | Poly RF(+) | Oligo persistent | Oligo extended | Psoriatic | ERA | Undiff | ||
(N = 355) | (N = 1313) | (N = 294) | (N = 1293) | (N = 340) | (N = 273) | (N = 451) | (N = 122) | ||
Any autoimmune disease | 77 (21.7) | 408 (31.1) | 87 (29.6) | 344 (26.6) | 97 (28.5) | 146 (53.5) | 186 (41.2) | 54 (44.3) | <0.001 |
Inflammatory arthritisc | 26 (7.3) | 169 (12.9) | 36 (12.4) | 137 (10.6) | 36 (10.6) | 5 2 (19.1) | 97 (21.5) | 24 (19.7) | <0.001 |
Ankylosing spondylitis | 0 (0.0) | 4 (0.3) | 1 (0.3) | 7 (0.5) | 0 (0.0) | 2 (0.7) | 37 (8.2) | 5 (4.1) | <0.001 |
Spondyloarthropathy | 1 (0.3) | 2 (0.2) | 1 (0.3) | 3 (0.2) | 0 (0.0) | 5 (1.8) | 17 (3.8) | 2 (1.6) | <0.001 |
JIA | 10 (2.8) | 83 (6.3) | 10 (3.4) | 67 (5.2) | 13 (3.8) | 13 (4.8) | 32 (7.1) | 5 (4.1) | 0.047 |
RA | 17 (4.8) | 95 (7.2) | 25 (8.5) | 76 (5.9) | 24 (7.1) | 37 (13.6) | 32 (7.1) | 16 (13.1) | <0.001 |
Crohn’s disease or ulcerative colitis | 4 (1.1) | 35 (2.7) | 7 (2.4) | 27 (2.1) | 6 (1.8) | 6 (2.2) | 26 (5.8) | 6 (4.9) | 0.001 |
Acute anterior uveitis | 0 (0.0) | 7 (0.5) | 0 (0.0) | 1 (0.1) | 1 (0.3) | 0 (0.0) | 6 (1.3) | 0 (0.0) | 0.005 |
Psoriasis | 20 (5.6) | 78 (5.9) | 11 (3.7) | 70 (5.4) | 17 (5.0) | 96 (35.2) | 31 (6.9) | 20 (16.4) | <0.001 |
SLE | 7 (2.0) | 26 (2.0) | 5 (1.7) | 17 (1.3) | 5 (1.5) | 2 (0.7) | 7 (1.6) | 5 (4.1) | 0.338 |
Multiple Sclerosis | 3 (0.9) | 14 (1.1) | 2 (0.7) | 10 (0.8) | 6 (1.8) | 3 (1.1) | 2 (0.4) | 3 (2.5) | 0.410 |
Autoimmune thyroiditis | 16 (4.5) | 74 (5.6) | 17 (5.8) | 62 (4.8) | 22 (6.5) | 23 (8.4) | 17 (3.8) | 6 (4.9) | 0.198 |
Celiac | 1 (0.3) | 7 (0.5) | 0 (0.0) | 15 (1.2) | 2 (0.6) | 0 (0.0) | 6 (1.3) | 1 (0.8) | 0.113 |
Type 1 Diabetes | 12 (3.4) | 41 (3.1) | 14 (4.8) | 32 (2.5) | 8 (2.4) | 11 (4.0) | 14 (3.1) | 6 (4.9) | 0.406 |
Other autoimmune | 12 (3.3) | 68 (5.1) | 10 (3.3) | 50 (3.8) | 12 (3.5) | 14 (5.1) | 25 (5.4) | 6 (4.7) | 0.504 |