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Table 4 Comparison of cases with different JIA categories with autoimmune disorders among first-degree relatives

From: Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

Family history of disease JIA categorya P-valueb
(N = 4441)
Systemic Poly RF(−) Poly RF(+) Oligo persistent Oligo extended Psoriatic ERA Undiff
(N = 355) (N = 1313) (N = 294) (N = 1293) (N = 340) (N = 273) (N = 451) (N = 122)
Any autoimmune disease 77 (21.7) 408 (31.1) 87 (29.6) 344 (26.6) 97 (28.5) 146 (53.5) 186 (41.2) 54 (44.3) <0.001
Inflammatory arthritisc 26 (7.3) 169 (12.9) 36 (12.4) 137 (10.6) 36 (10.6) 5 2 (19.1) 97 (21.5) 24 (19.7) <0.001
 Ankylosing spondylitis 0 (0.0) 4 (0.3) 1 (0.3) 7 (0.5) 0 (0.0) 2 (0.7) 37 (8.2) 5 (4.1) <0.001
 Spondyloarthropathy 1 (0.3) 2 (0.2) 1 (0.3) 3 (0.2) 0 (0.0) 5 (1.8) 17 (3.8) 2 (1.6) <0.001
 JIA 10 (2.8) 83 (6.3) 10 (3.4) 67 (5.2) 13 (3.8) 13 (4.8) 32 (7.1) 5 (4.1) 0.047
 RA 17 (4.8) 95 (7.2) 25 (8.5) 76 (5.9) 24 (7.1) 37 (13.6) 32 (7.1) 16 (13.1) <0.001
Crohn’s disease or ulcerative colitis 4 (1.1) 35 (2.7) 7 (2.4) 27 (2.1) 6 (1.8) 6 (2.2) 26 (5.8) 6 (4.9) 0.001
Acute anterior uveitis 0 (0.0) 7 (0.5) 0 (0.0) 1 (0.1) 1 (0.3) 0 (0.0) 6 (1.3) 0 (0.0) 0.005
Psoriasis 20 (5.6) 78 (5.9) 11 (3.7) 70 (5.4) 17 (5.0) 96 (35.2) 31 (6.9) 20 (16.4) <0.001
SLE 7 (2.0) 26 (2.0) 5 (1.7) 17 (1.3) 5 (1.5) 2 (0.7) 7 (1.6) 5 (4.1) 0.338
Multiple Sclerosis 3 (0.9) 14 (1.1) 2 (0.7) 10 (0.8) 6 (1.8) 3 (1.1) 2 (0.4) 3 (2.5) 0.410
Autoimmune thyroiditis 16 (4.5) 74 (5.6) 17 (5.8) 62 (4.8) 22 (6.5) 23 (8.4) 17 (3.8) 6 (4.9) 0.198
Celiac 1 (0.3) 7 (0.5) 0 (0.0) 15 (1.2) 2 (0.6) 0 (0.0) 6 (1.3) 1 (0.8) 0.113
Type 1 Diabetes 12 (3.4) 41 (3.1) 14 (4.8) 32 (2.5) 8 (2.4) 11 (4.0) 14 (3.1) 6 (4.9) 0.406
Other autoimmune 12 (3.3) 68 (5.1) 10 (3.3) 50 (3.8) 12 (3.5) 14 (5.1) 25 (5.4) 6 (4.7) 0.504
  1. achildren with missing JIA category information were excluded. All values are N (%)
  2. bSignificance values for overall differences between JIA categories
  3. cInflammatory arthritis includes AS, spondyloarthropathy, JIA and RA