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Table 2 Comparison of cases with JIA, cSLE and JDM with autoimmune disorders among first-degree relatives

From: Familial autoimmunity in the childhood arthritis and rheumatology research alliance registry

Family history of disease Disease group P-value
JIA cSLE JDM
(N = 4,677) (N = 639) (N = 440)
Any autoimmune disease 1,488 (31.8) 204 (31.9) 90 (20.5)a b <0.001
Inflammatory Arthritis -(AS, Spondyloarthropathy, JIA, RA) 608 (13.0) 59 (9.2)a 19 (4.3)a b <0.001
 Ankylosing spondylitis 61 (1.3) 1 (0.2)a 2 (0.5) 0.014
 Spondyloarthropathy 36 (0.8) 0 (0.0) 0 (0.0) 0.015
 JIA 241 (5.2) 14 (2.2)a 4 (0.9)a <0.001
 RA 340 (7.3) 50 (7.8) 15 (3.4)a b 0.007
Crohn’s disease or ulcerative colitis 126 (2.7) 4 (0.6)a 5 (1.1) 0.002
Acute anterior uveitis 15 (0.3) 0 (0.0) 0 (0.0) 0.169
Psoriasis 372 (8.0) 16 (2.5)a 22 (5.0) <0.001
SLE 77 (1.7) 71 (11.1)a 5 (1.1)b <0.001
Multiple Sclerosis 45 (1.0) 7 (1.1) 5 (1.1) 0.905
Autoimmune thyroiditis 248 (5.3) 17 (2.7)a 24 (5.5) 0.015
Celiac 36 (0.8) 5 (0.8) 6 (1.4) 0.439
Type 1 Diabetes 147 (3.1) 47 (7.4)a 13 (3.0)b <0.001
Other autoimmune 214 (4.6) 32 (5.0) 20 (4.6) 0.893
  1. All values are N (%)
  2. aSignificantly different from JIA (p < 0.017)
  3. bSignificantly different from SLE (p < 0.017)