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Table 2 Top ten IPA pathways that were found to be significantly altered in PBMC and neutrophil samples from sJIA patients responding to tocilizumab

From: Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study

PBMCa Neutrophils
Oncostatin M signalling (3) Mitochondrial dysfunction (20)
Natural killer cell signalling (5) EIF2 signalling (23)
Glutamine biosynthesis I (1) NRF2-mediated oxidative stress response (20)
B Cell receptor signalling (6) Calcium-induced T lymphocyte apoptosis (9)
PPARα/RXRα activation (6) mTOR signalling (20)
Thyroid hormone biosynthesis (1) Sucrose degradation V (Mammalian) (3)
  Regulation of eIF4 and p70S6K signalling (16)
  TCA cycle II (Eukaryotic) (5)
  CTLA4 signalling in cytotoxic T lymphocytes (11)
  Protein ubiquitination pathway (24)
  1. aThere were only 6 significant canonical pathways for this condition. In brackets are the numbers of genes from the input file in each pathway