Table 2 Top ten IPA pathways that were found to be significantly altered in PBMC and neutrophil samples from sJIA patients responding to tocilizumab
PBMCa | Neutrophils |
|---|---|
Oncostatin M signalling (3) | Mitochondrial dysfunction (20) |
Natural killer cell signalling (5) | EIF2 signalling (23) |
Glutamine biosynthesis I (1) | NRF2-mediated oxidative stress response (20) |
B Cell receptor signalling (6) | Calcium-induced T lymphocyte apoptosis (9) |
PPARα/RXRα activation (6) | mTOR signalling (20) |
Thyroid hormone biosynthesis (1) | Sucrose degradation V (Mammalian) (3) |
| Â | Regulation of eIF4 and p70S6K signalling (16) |
| Â | TCA cycle II (Eukaryotic) (5) |
| Â | CTLA4 signalling in cytotoxic T lymphocytes (11) |
| Â | Protein ubiquitination pathway (24) |