Relationship of cell-free urine MicroRNA with lupus nephritis in children

Table 3 Associations of MiRNA and LN-Panel levels in the urine supernatant vs. traditional measures^a

Variables^b	miR125a	miR127	miR146a	miR150	miR155	Tf	BTP	NGAL	MCP-1
LN-Panel
Transferrin (Tf)	0.44	−0.24	-	0.65	0.54	1.0	-	0.42	0.27
BTP	0.73	−0.24	−0.37	0.68	0.35	-	1.0	0.43	0.21
NGAL	0.48	-	−0.27	0.39	-	-	-	1.0	0.58
MCP-1	0.44	0.34	-	0.45	0.68	-	-	-	1.0
WBC (k/mcL)	0.23	-	-	0.40	-	0.30	0.25	-	0.37
Hemoglobin (mg/dL)	-	-	-	-	-	−0.21	0.42	-	-
Platelets count (k/mcL)	−0.39	−0.24	-	-	-	-	0.25	−0.27	−0.21
ESR (mm/h)	-	0.24	-	-	-	-	0.25	-	0.36
Anti-dsDNA titer	-	−0.31	−0.28	-	−0.27		-	0.5	0.36
C3 level (mg/dL)	−0.32	-	0.24	--	−0.36	0.23	−0.43	−0.41	−0.2
C4 level (mg/dL)	-	-	-	-	−0.29	-	−0.26	−0.31	−0.21
Urine P/C ratio	-	-	-	0.38	0.36	-	-	-	-
GFR	-	-	-			−0.21
Renal - SLEDAI^d	-	-	−0.32	-	-	0.46	0.30	0.53	0.49
Renal BILAG^e	0.29	-	0.29	0.27	0.20	0.46	0.26	0.48	0.31
Extrarenal SLEDAI^c	-	-	-	-	-	-	-	-	-

^aOnly statistically significant associations with r values ≥ 0.20 are shown; “-“means, no statistically significant correlation was found (p > 0.05)
^bValues are Pearson correlation coefficients of log-transformed urine concentrations the miRNAs listed with miR micro RNA, BTP beta trace protein, NGAL neutrophil gelatinase associated lipocalin, MCP monocyte chemotactic protein 1, WBC white blood count, DSDNA anti-double stranded DNA titer, GFR glomerular filtration rate, P/C protein to creatinine
^cSLEDAI, Systemic Lupus Erythematosus Disease Activity Index, range 0–105; 0 inactive LN
^dRenal-SLEDAI, renal domain of the Systemic Lupus Erythematosus Disease Activity Index
^eRenal-BILAG, renal domain of the British Isles Lupus Activity Group Index

ISSN: 1546-0096