Skip to main content

Table 3 Associations of MiRNA and LN-Panel levels in the urine supernatant vs. traditional measuresa

From: Relationship of cell-free urine MicroRNA with lupus nephritis in children

Variablesb miR125a miR127 miR146a miR150 miR155 Tf BTP NGAL MCP-1
LN-Panel          
 Transferrin (Tf) 0.44 −0.24 - 0.65 0.54 1.0 - 0.42 0.27
 BTP 0.73 −0.24 −0.37 0.68 0.35 - 1.0 0.43 0.21
 NGAL 0.48 - −0.27 0.39 - - - 1.0 0.58
 MCP-1 0.44 0.34 - 0.45 0.68 - - - 1.0
WBC (k/mcL) 0.23 - - 0.40 - 0.30 0.25 - 0.37
Hemoglobin (mg/dL) - - - - - −0.21 0.42 - -
Platelets count (k/mcL) −0.39 −0.24 - - - - 0.25 −0.27 −0.21
ESR (mm/h) - 0.24 - - - - 0.25 - 0.36
Anti-dsDNA titer - −0.31 −0.28 - −0.27   - 0.5 0.36
C3 level (mg/dL) −0.32 - 0.24 -- −0.36 0.23 −0.43 −0.41 −0.2
C4 level (mg/dL) - - - - −0.29 - −0.26 −0.31 −0.21
Urine P/C ratio - - - 0.38 0.36 - - - -
GFR - - -    −0.21    
Renal - SLEDAId - - −0.32 - - 0.46 0.30 0.53 0.49
Renal BILAGe 0.29 - 0.29 0.27 0.20 0.46 0.26 0.48 0.31
Extrarenal SLEDAIc - - - - - - - - -
  1. aOnly statistically significant associations with r values ≥ 0.20 are shown; “-“means, no statistically significant correlation was found (p > 0.05)
  2. bValues are Pearson correlation coefficients of log-transformed urine concentrations the miRNAs listed with miR micro RNA, BTP beta trace protein, NGAL neutrophil gelatinase associated lipocalin, MCP monocyte chemotactic protein 1, WBC white blood count, DSDNA anti-double stranded DNA titer, GFR glomerular filtration rate, P/C protein to creatinine
  3. cSLEDAI, Systemic Lupus Erythematosus Disease Activity Index, range 0–105; 0 inactive LN
  4. dRenal-SLEDAI, renal domain of the Systemic Lupus Erythematosus Disease Activity Index
  5. eRenal-BILAG, renal domain of the British Isles Lupus Activity Group Index