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Table

From: Primary angiitis of the central nervous system in children - case series

Patient 1 2 3 4 5 6 7
Age at onset (years) 13 1,5 12 16 5,5 6 15
Time to diagnosis (months) 30 5 1 1,5 12 1 1,5
F/U (years) 4 13 5 0,5 2 1,5 1
Manifestation at onset generalised seizures focal seizure, stroke seizure sensory deficit sensory deficit, stroke stroke stroke with ataxia seizures stroke
MRI at onset UL, MF UL, MF BL, MF BL,MF UL,MF UL, F UL,MF
Angiography at onset N/D posit. posit. posit. posit. posit. neg.
Initial therapy AED AED ACA ACA, CS 0 ACA IVMP, AED
Manifestation at F/U seizures cognitive dysfunction hemiparesis developmental delay normal normal cognitive dysfunction, hemiparesis normal organic psychosis
MRI at F/U BL, MF N/D N/D N/D BL, MF regression BL, MF
Angiography F/U neg. N/D N/D N/D regression regression neg.
Therapy at F/U AED, CS AED, ACA ACA CS ACA ACA CYC, CS
  1. ACA - acetylsalicylic acid, AED - anti-epileptic drugs, CS - oral corticosteroid (prednisone or methylprednisolone), CYC - cyclophosphamide, IVMP- intravenous methylprednisolone, N/D- not done