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Serum amyloid A circulating levels and disease activity in patients with juvenile idiopathic arthritis

  • L Cantarini1,
  • MG Brizi1,
  • G Simonini2,
  • T Giani2,
  • A Vitale1,
  • A Fioravanti1,
  • MR Bacarelli1,
  • Galeazzi Mauro1 and
  • R Cimaz2
Pediatric Rheumatology20119(Suppl 1):P315

Published: 14 September 2011


ArthritisErythrocyte Sedimentation RateSignificant Positive CorrelationJuvenile Idiopathic ArthritisSpondylitis


Serum amyloid A (SAA) has been shown to correlate with disease activity in ankylosing spondylitis, and its superiority to erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) has been suggested.


Our aim was to evaluate the association SAA circulating levels and disease activity in patients with juvenile idiopathic arthritis (JIA)


Our study group included 41 JIA patients (9 male, 32 female), classified according to the ILAR criteria; 16 had polyarticular disease and 25 had oligoarticular disease; 3/25 patients with oligoarticular diseases had extended oligoarthritis. Serum SAA, ESR and CRP were measured both in patients and 26 healthy controls.


SAA levels were higher in JIA patients versus healthy controls (p<0.001). Significant positive correlations were found between SAA and the presence of active joints (p<0.05), the number of active joints (p<0.05), ESR (p<0.05) and CRP (p<0.05). No significant correlations between ESR and the presence of active joints (p=0.225) or between ESR and the number of active joints (p=0.520) were demonstrated in JIA patients. No significant correlations were obtained between CRP and the presence of active joints (p=0.855), or between CRP and the number of active joints (p=0.859).


We found a significant increase of SAA levels in JIA patients as compared to controls, and a strong positive correlation between SAA level and JIA disease activity. We also determined SAA to be a more sensitive laboratory marker than ESR or CRP when compared with the presence and with the number of active joints. We suggest that SAA can be used as an additional indicator of disease activity in JIA.

Authors’ Affiliations

Rheumatology Unit, Department of Clinical Medicine and Immunologic Sciences, University of Siena, Italy
Department of Paediatrics, Rheumatology Unit, Anna Meyer Children's Hospital and University of Florence, Italy


© Cantarini et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.