Skip to main content

Association of the polymorphisms P53 gene with juvenile idiopathic arthritis in children Russian Fedration


Juvenile idiopathic arthritis – is a chronic systemic autoimmune disease that is a characterized by articular lesion with synovial hyperplasia and cellular infiltration. Arg72Pro (4ex) and ins/del 16bp (3in) polymorphisms are associated with affects the functional activity of the p53 protein. (P.Dumont et al, 2003)


The purpose of our study is estimate course and outcomes of juvenile idiopathic arthritis of the children with various genotypes of p53.


We examined 58 children with juvenile idiopathic arthritis. Clinical, serological and x-ray manifestations were analyzed in children and correlated with the genotypes. For detection erosion bone process we used ultrasound, x-ray, MRI and diagnostic arthroscopy with synovial biopsy. We investigated (PCR-RFLP) the status of p53 gene this children with juvenile idiopathic arthritis and 100 healthy children living in Russian Federation.


Genotypes distributions of Arg72Pro and ins/del 16bp polymorphisms did not differ significantly (p>0,05) between JIA patients and controls. Children with mild form oligo-, polyarthritis JIA achieved remission had significantly higher percentage genotype Arg/Arg+del/del compared children with severe oligo, polyarthritis duration more 5 years (89,7 vs 23,8%, p<0,01). Young girls with severe oligoarthirits, ANA-positive and erosion joint process had a significantly higher percentage of genotype Arg/Pro+ins/del compared children with mild form oligoarthritis, ANA-negative (87,5 vs 9%, p<0,01). Girls with severe polyarthritis DAS44 4.0±1.1 had significant high percentage genotype Arg/Pro+ins/del compared children with mild form polyarthritis DAS44 2.4±0.9 (67 vs 9%, p<0,01).


Girls with genotype Arg/Pro+ins/del p53 had more severe and aggressive form oligo-polyarthritis manifested by erosion process.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Kozhevnikov, A.N., Moskalenko, M.V., Pozdeeva, N.A. et al. Association of the polymorphisms P53 gene with juvenile idiopathic arthritis in children Russian Fedration. Pediatr Rheumatol 9 (Suppl 1), P282 (2011).

Download citation

  • Published:

  • DOI:


  • Juvenile Idiopathic Arthritis
  • Mild Form
  • Erosion Bone
  • Systemic Autoimmune Disease
  • Joint Process