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A year in the life of the streptococcus


Mild streptococcal infections infection are extremely common, however invasive infections can lead to high mortality rates. Described in 1982, post streptococcal reactive arthritis (PSRA) has been reported with increasing frequency.


We aimed to look at the number of children presenting to a Tertiary Children’s Hospital, with serological significant streptococcal illnesses, diagnoses and antibiotic treatment of those patients.


Over a One year period of ASOT ( anti streptolysin O) results from a tertiary Children’s Hospital were reviewed. The ASOT results documented, paired data of ASOT & Anti DNase B (anti Deoxyribonuclease B antibodies) reviewed for correlation. Diagnoses were obtained using clinical notes.

Throat swabs results were reviewed where performed. The antibiotic treatment advised documented.


ASOT January 2009- December 2010 = 645

N° patients=359

N° ASOT’s >400 = 100 (28 %)

Notes reviewed = 95/100 patients

Table 1
Table 2

Where both ASOT and Anti DNAse B were performed simultaneously (No =194), results correlated in 88%

Throat Swab performed in the group with ASOT >400 = 43/100

65 % patients with ASOT >400 were prescribed antibiotics


Nearly 1/5 of patients with positive streptococcal serology had a rheumatological diagnosis, suggesting it is a significant trigger in rheumatological conditions.

This study highlights vigilance and alertness that patients with Streptococcal Infections may evolve or contribute to the development of a rheumatogical condition.

There is a need for a consensus opinion on treatment and eradication of streptococcal infection.

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Correspondence to ET Mosley.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mosley, E., McMahon, A., Shackley, F. et al. A year in the life of the streptococcus. Pediatr Rheumatol 9 (Suppl 1), P213 (2011).

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