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  • Open Access

Effect of ANA positivity on clinical picture of the JIA: should ANA positive JIA be classified as a different group?

  • 1Email author,
  • 1,
  • 2,
  • 3,
  • 4,
  • 5,
  • 6,
  • 7,
  • 1,
  • 3 and
  • 1
Pediatric Rheumatology20119 (Suppl 1) :P156

https://doi.org/10.1186/1546-0096-9-S1-P156

  • Published:

Keywords

  • Uveitis
  • Rheumatoid Factor
  • Multivariate Regression
  • Multivariate Regression Analysis
  • Negative Group

Background

According to ILAR classification, JIA is classified into 7 different categories based on similar characteristic features of each.

Aim

In this study we aimed to investigate whether ANA positive patients in different ILAR categories constitute a homogenous group.

Methods

In this cross-sectional study, patients who had been followed up for at least a 6 month-period were recruited from different centers and registered thorough a web-based registry. Patients were grouped according to their ANA positivity. Clinical and demographic features were compared between ANA positive and negative groups. The results were explored by univariate and multivariate regression analysis (OR, %95 CI).

Results

A total number of 402 JIA patients of which 169 ANA positive and 233 ANA negative were enrolled in the study. The mean age of the diagnosis in ANA negative and positive groups were 4.65 ± 3.48 and 4.01 ± 2.86 respectively; and female-male ratio for ANA negative and positive groups were 1.3 (135/98) and 4.1 (136/33) respectively. The subgroups of the patients according to ILAR classification system are listed in the table.

According to our results of multipl regression analysis, the variables which demonstrated statisticly significant association with ANA presence were female sex (OR =3.763 (2.26-6.27)), uveitis (OR=5.58 (2.21-14.10)), rheumatoid factor positivity (OR=4.07 (1.34-12.36)), high levels of ESR (OR 0.993 (0.985-1.00)) and small joint involvement (OR 0.57 (0.31-1.03)).

Conclusion

Our results indicate that, ANA positive patients classified in different groups by using current ILAR classification system, demonstrate similar clinical and laboratory findings. Thus we suggest that ANA status may be used as a parameter for classification of JIA.

Table 1

 

ANA negative

ANA pozitive

P

 

n

%

n

%

 

Oligoarticular persistent

113

48,5

121

71,6

<0,001

Oligoarticular extended

11

4,7

15

8,9

 

Polyarticular RF (-)

99

42,5

30

17,8

 

Psoriatic

10

4,3

3

1,8

 

Total

233

100

169

100

 

Authors’ Affiliations

(1)
Gülhane Military Medical Academy, Pediatric Nephrology & Rheumatology Unit, Ankara, Turkey
(2)
Department of Public Health, Division of Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey
(3)
Hacettepe University Medical School, Pediatric Nephrology & Rheumatology Unit, Ankara, Turkey
(4)
Dokuz Eylul University Medical School, Pediatric Immunology and Rheumatology Unit, İzmir, Turkey
(5)
Division of Pediatric Rheumatology, Goztepe Training and Research Hospital, Istanbul, Turkey
(6)
Erciyes University Medical School, Pediatric Nephrology & Rheumatology Unit, Kayseri, Turkey
(7)
Istanbul University Cerrahpasa Medical School Department of Pediatric Rheumatology, Istanbul, Turkey

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