Volume 9 Supplement 1
Tocilizumab-effects on growth impairment in systemic juvenile idiopathic arthritis
© Miyamae et al; licensee BioMed Central Ltd. 2011
Published: 14 September 2011
Systemic juvenile idiopathic arthritis (s-JIA) is a subtype of chronic childhood arthritis of unknown etiology. The anti-IL-6 receptor monoclonal antibody, tocilizumab (TCZ), was developed, and we investigated the safety and efficacy of TCZ in children with this disorder.
Growth analysis during the study was performed.
Forty-five s-JIA patients (17 boys and 28 girls, 8.1±4.2 years of age, disease duration 4.1±3.2 years) who completed 144 visit (ca. 3 years) of phase-III study of TCZ were enrolled. The study had 6 week open-label phase (8mg/kh q2W) followed by 12 week randomized, double-blind withdrawal phase (8mg/kg q2w or placebo q2w).
Mean standard deviation score (SDS) for height, changes in SDS from baseline (⊿SDS), correlation between ⊿SDS and several factors such as age, gender, disease duration, corticosteroid dose exposure during the study, JIA core set response were evaluated. SDS for height calculated against the growth curve for Japanese population was used growth analysis.
Growth impairments evidenced by SDS-height were more prominent in patients with longer standing disease, which means importance of earlier intervention in the disease course. Catch up growth was observed in patients who required less or no corticosteroid during TCZ treatment for 3 years.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.