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  • Poster presentation
  • Open Access

Efficacy of abatacept in juvenile idiopathic arthritis related uveitis

  • 1,
  • 1,
  • 1,
  • 1 and
  • 2
Pediatric Rheumatology20119 (Suppl 1) :P100

https://doi.org/10.1186/1546-0096-9-S1-P100

  • Published:

Keywords

  • Glaucoma
  • Infliximab
  • Cataract
  • Juvenile Idiopathic Arthritis
  • Uveitis

Background

Despite various immunosuppressive agents, juvenile idiopathic arthritis (JIA) related uveitis often take a serious course that leads to sight threatening complications.

Aim

To evaluate efficacy of Abatacept in combined treatment of JIA related uveitis.

Methods

10 children aged 4 – 12 years with anterior uveitis associated with JIA were treated by Abatacept in standard infusions pattern and doses. Indication for using Abataceptwas ineffectiveness of standard therapy of arthritis and/or uveitis. 6 patients were suffering from polyarticular variants, 4 – oligoarticular JIA. Abatacept was combined with Methotrexate in 9, Sulfasalazin in 1 and low-dose steroids in 4 children. 3 patients were switched to Abatacept from Infliximab due to non-efficacy, 7 received abatacept as a first line biologic. 9 patients had bilateral eye involvement. At the administration of Abatacept severe inflammation was seen in 1, moderate in 7, mild in 2 of the cases. Follow up period ranged from 3 to 11 month (mean 7.6). The main outcome measure was the degree of inflammation.

Results

Remission of uveitis in current treatment was achieved in 6 (60%), improvement in the degree of inflammation in 2 (20%) of the cases. The initial response was seen after the 2nd – 4th injection. From patients switched from Infliximab to Abatacept 1 achieved remission of uveitis, 1 improved, 1 remained stable. Patients with remission of uveitis diminished or discontinued topical medications. No ocular or systemic adverse effects were observed. Glaucoma or cataract surgery was uncomplicated in all 4 cases.

Conclusions

Administration of Abatacept was effective in 80% of children with JIA related uveitis. Further investigations are required to define clear indications for this treatment in severe uveitis.

Authors’ Affiliations

(1)
Helmholtz Research Institute of Eye Diseases, Moscow, Russia
(2)
Scientific Research Institute of Rheumatology of Russian Academy of Medical Sciences, Moscow, Russia

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