Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor-positive polyarticular juvenile idiopathic arthritis

Table 4 Significant differences in antibody levels in JIA patients positive versus negative for anti-citrullinated fibrinogen antibodies

	Positive for Anti-Citrullinated Fibrinogen Antibodies n = 31	Negative for Anti-Citrullinated Fibrinogen Antibodies n = 65	P-Value
IgM RF (U)	42.86	6.59	< 0.001
IgA RF (U)	15.27	1.25	0.005
IgG anti-CCP Antibodies (U)	65.64	0.86	0.001
IgA anti-CCP Antibodies (OD)	0.22	0.05	0.026
IgM anti-CCP Antibodies (OD)	0.69	0.32	0.009

Anti-CCP antibodies: anti-cyclic citrullinated peptide antibodies; n = number of patients; OD = optical density; RF = rheumatoid factor; U: Units. Cut points for positive values: Anti-citrullinated fibrinogen antibodies (OD≥0.59), IgG anti-CCP antibodies (≥20U), IgA anti-CCP antibodies (OD≥0.16), IgM anti-CCP antibodies (OD≥0.43), IgA RF (≥6U), IgM RF (≥6U). P-value < 0.05 was considered statistically significant.

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