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Table 3 Comparison of post-streptococcal reactive arthritis (PSRA) and acute rheumatic fever (ARF)

From: Post-streptococcal reactive arthritis in children: a distinct entity from acute rheumatic fever

  PSRA ARF
Age Bimodal: 8-14 years and 21-37 years 5-15 years with peak incidence around 12 years
Disease onset post streptococcal infection 7-10 days 10-28 days
Joint involvment Additive and persistent; large, small and axial joints Migratory, transient; mainly large joints
Acute phase reactants Moderatly elevated Markedly elevated
Response of arthritis to acetylsalicylic acid or NSAID treatment Poor to moderate Dramatic
Genetic markers Increased frequency of HLA DRB1*01 Increased frequency of the HLA DRB1*16 allele
Carditis Conflicting reports, but uncommon Major diagnostic criteria, between 60-70%
Antibiotic prophylaxis Antibiotic prophylaxis for one year if echocardiogram is normal Long-term secondary antibiotic prophylaxis
  1. NSAID: Non-steroidal antiinflammatory drugs