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Table 5 Markers of bone mineralization and metabolism in JIA girls with polymorphic GR genotypes.

From: Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis

Parameter

CC

GC

GG

p1

p2

p3

ВА, см2

51.9 ± 11.0

38.0 ± 12.6

32.3 ± 13.5

0.00005

0.11

0.0001

BMC, grams

43.5 ± 13.8

28.1 ± 16.8

19.6 ± 15.2

0.0004

0.07

0.00007

BMD, gms/см2

0.816 ± 0.15

0.677 ± 0.22

0.566 ± 0.19

0.005

0.06

0.048

BMD - Zscore (SD)

0.03 ± 0.85

0.007 ± 0.9

-0.931 ± 0.88

0.46

0.003

0.002

Osteocalcin, ng/ml

82.5 ± 5.1

87.3 ± 44.8

114.3 ± 39.8

0.37

0.05

0.03

CTТ, ng/ml

0.95 ± 0.34

1.02 ± 0.37

1.24 ± 0.42

0.28

0.09

0.036

PTH, pmol/ml

2.29 ± 1.23

1.9 ± 0.83

2.08 ± 0.64

0.11

0.25

0.26

Ca, mmol/l

2.4 ± 0.15

2.36 ± 0.14

2.38 ± 0.13

0.09

0.29

0.29

Ca++, mmol/l

1.02 ± 0.12

1.05 ± 0.11

1.1 ± 0.11

0.18

0.07

0.017

P inorganic, mmol/l

1.54 ± 0.2

1.61 ± 0.2

1.55 ± 0.2

0.1

0.23

0.44

TAP, U/l

293.5 ± 119.8

360.8 ± 116.1

328.8 ± 115.8

0.01

0.19

0.17

  1. р1 - comparison between carriers СС and GC genotypes
  2. р2 - comparison between carriers GC and GG genotypes
  3. р3 - comparison between carriers СС and GG genotypes