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Table 5 Markers of bone mineralization and metabolism in JIA girls with polymorphic GR genotypes.

From: Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis

Parameter CC GC GG p1 p2 p3
ВА, см2 51.9 ± 11.0 38.0 ± 12.6 32.3 ± 13.5 0.00005 0.11 0.0001
BMC, grams 43.5 ± 13.8 28.1 ± 16.8 19.6 ± 15.2 0.0004 0.07 0.00007
BMD, gms/см2 0.816 ± 0.15 0.677 ± 0.22 0.566 ± 0.19 0.005 0.06 0.048
BMD - Zscore (SD) 0.03 ± 0.85 0.007 ± 0.9 -0.931 ± 0.88 0.46 0.003 0.002
Osteocalcin, ng/ml 82.5 ± 5.1 87.3 ± 44.8 114.3 ± 39.8 0.37 0.05 0.03
CTТ, ng/ml 0.95 ± 0.34 1.02 ± 0.37 1.24 ± 0.42 0.28 0.09 0.036
PTH, pmol/ml 2.29 ± 1.23 1.9 ± 0.83 2.08 ± 0.64 0.11 0.25 0.26
Ca, mmol/l 2.4 ± 0.15 2.36 ± 0.14 2.38 ± 0.13 0.09 0.29 0.29
Ca++, mmol/l 1.02 ± 0.12 1.05 ± 0.11 1.1 ± 0.11 0.18 0.07 0.017
P inorganic, mmol/l 1.54 ± 0.2 1.61 ± 0.2 1.55 ± 0.2 0.1 0.23 0.44
TAP, U/l 293.5 ± 119.8 360.8 ± 116.1 328.8 ± 115.8 0.01 0.19 0.17
  1. р1 - comparison between carriers СС and GC genotypes
  2. р2 - comparison between carriers GC and GG genotypes
  3. р3 - comparison between carriers СС and GG genotypes