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Table 1 Characteristics of patients with JIA and healthy children at baseline and 2-year follow-up*

From: Serum levels of osteoprotegerin and receptor activator of nuclear factor -κB ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study

 

Baseline

2 year follow-up

 

JIA patients(n = 90)

Controls(n = 90)

JIA patients(n = 90)

Controls(n = 90)

Characteristics

    

Female, n (%)

56 (62%)

56 (62%)

56 (62%)

56 (62%)

Age, mean (SD) years

10.1 (3.2)

10.1 (3.2)

12.1 (3.2)

12.2 (3.2)

Disease-onset type, n (%)

    

   Oligoarthritis, persistent

48 (53%)

-

48 (53%)

-

   Oligoarthritis, extended

11 (12%)

-

11 (12%)

-

   Polyarthritis, RF negative

28 (31%)

-

28 (31%)

-

   Polyarthritis, RF positive

3 (3%)

-

3 (3%)

-

Disease duration, mean (SD) months

19.4 (12.3)

-

44.3 (14.2)

-

No. of joints with active disease, mean (SD) †

2.2 (3.5)

-

1.3 (4.2)

-

No. of joints with restricted mobility, mean (SD) †

1.7 (2.6)

-

1.2 (2.2)

-

Radiographic score, mean (SD) ‡

1.7 (0.6)

-

1.8 (0.6)

-

Radiographic erosions, n (%) §

3 (3%)

-

5 (6%)

-

Radiographic progression, n (%)¶

-

-

9 (10%)

-

Total body BMC Z-score < -1, n (%)

10 (11%)

9 (10%)

20 (22%)

12 (13%)

Disease-modifying antirheumatic drugs, current use, n (%)

48 (53%)

-

37 (41%) #

-

Non-steroidal anti-inflammatory drugs, current use, n (%)

68 (76%)

 

43 (48%)

 

Oral corticosteroids **

    

   Current use, n (%)

17 (19%)

-

8 (9%)

-

Dosage, mean (SD) mg/day

11.2 (7.1)

-

6.7 (5.9)

-

   Ever used, n (%)

27 (30%)

-

31 (34%)

-

Cumulative dose, mean (SD) mg

1234 (1328)

-

1919 (2062)

-

Cumulative dose, mean (SD) mg/kg of body weight

38 (42)

-

52 (65)

-

  1. * Because of rounding, not all percentages total 100. JIA = juvenile idiopathic arthritis; RF = rheumatoid factor; BMC = bone mineral content.
  2. † Sixty-nine joints were evaluated.
  3. ‡ Highest registered score from a range of 0 = best to 5 = worst.
  4. § Erosions = radiographic grade 3 or higher.
  5. ¶ Increase in radiographic grade from baseline to follow-up.
  6. # Methotrexate (n = 24), hydroxychloroqine (n = 8), methotrexate plus hydroxychloroqine (n = 3), methotrexate plus sulfasalazine (n = 1) and methotrexate plus etanercept (n = 1).
  7. ** Prednisolone. None of the patients had taken methylprednisolone.