Changes in serum levels, radiographic score and total body BMC at 2-year follow-up in patients with JIA. Changes in serum levels from baseline to follow-up: A. OPG/RANKL ratio. B. CRP. The legends for radiographic score and total body BMC is valid for panel A and B. Radiographic score grade 0 = normal joints; grade 1 = swelling/osteopoprosis; grade 2 = abnormal growth; grade 3 = abnormal growth and erosions; BMC Z-score > -1 SD defined as normal; BMC Z-score between -1 SD and -2 SD defined as low; BMC Z-score < -2 SD defined as very low. p Values by one-way analysis of variance, using the Bonferroni correction for multiple comparisons within the groups. Values are the mean. Error bars represent standard error of the mean.