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Table 4 Sample sizes requirements for genetic association studies

From: A comprehensive review of the genetics of juvenile idiopathic arthritis

MAF 10% 20% 30% 40%
  Cases controls Cases controls Cases Controls Cases Controls
OR         
2.0 223 446 137 274 113 226 107 214
1.5 703 1406 415 830 332 664 304 608
1.3 1751 3502 1016 2032 798 1596 719 1438
  1. Table shows number of cases and controls that need to be typed to detect associations at a significance value of 0.05, power of 80%, for various minor allele frequencies, and odds ratios. A case: control ratio of 1:2 is assumed. OR: odds ratio; MAF: minor allele frequency.