Skip to main content
  • Poster presentation
  • Open access
  • Published:

Could pentraxin-3 be a new marker for subclinical inflammation in familial Mediterranean fever?


Pentraxin-3 (PTX-3) is a long pentraxin that is structurally related to the short pentraxins as C-reactive protein (CRP). It is known to play an important role in innate immunity and inflammatory regulation. CRP and serum amyloid A (SAA) are sensitive and reliable markers of inflammation in FMF attack as well as chronic and subclinical inflammation during attack-free period. To date, there is no information about PTX-3 in FMF inflammation.


The aim of the study was to investigate the progress of serum PTX-3 levels together with traditional acute phase reactants in FMF patients during attack and attack free period (two weeks after the attack) and also assess whether PTX-3 could be related with subclinical inflammation.

Material and method

A prospective cross-sectional study was conducted between June 2013 and July 2014. A total of 45 consecutive children with FMF who were diagnosed according to the Tel-Hashomer and Yalçınkaya criteria were enrolled during the attack period. Blood samples were obtained from the patients during attack and attack free period (two weeks after the attack) and healthy children who were matched in terms of age and sex.


The study group consisted of 45 children with FMF (24 boys, 21 girls, mean age 9.5±3.8 years) and 40 healthy children. In FMF patients attack white blood cell (WBC) count, CRP, erythrocyte sedimentation rate (ESR), fibrinogen, SAA and PTX-3 levels were significantly higher than attack-free period and healthy subjects. In attack-free period, there were no significant differences between patients and healthy children in terms of WBC, CRP levels. Although mean attack-free period ESR, fibrinogen and SAA levels were higher than the controls, those markers were within the normal range. Whereas, mean attack-free PTX-3 level was still significantly higher than controls.

Table 1


Serum PTX-3 levels increased during the attacks of FMF and decreased during the attack free period however mean level of it was still higher than healthy subjects. We suggest that PTX-3 might be a new marker for both attack period and subclinical inflammation in FMF patients.

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yüksel, S., Karadağlı, E., Evrengül, H. et al. Could pentraxin-3 be a new marker for subclinical inflammation in familial Mediterranean fever?. Pediatr Rheumatol 13 (Suppl 1), P98 (2015).

Download citation

  • Published:

  • DOI: