Skip to main content


Diet and diet combined with chronic aerobic exercise decreases body fat mass and alters plasma and adipose tissue inflammatory markers in obese women

Article metrics

The purpose of this study was to investigate the effect of 6 months aerobic exercise and diet alone or in combination on markers of inflammation (MOI) in circulation and in adipose abdominal tissue (AT) in obese women. Thirty obese subjects were randomized into a 24 weeks intervention: 1) exercise (EX), 2) diet (DI) and 3) exercise and diet (EXD). Blood samples were collected at baseline, after 12 wk and 24 wk. AT biopsies were obtained only at baseline and after 24 wk. In the EXD and DI groups the fat loss was after 12 wk -13.74% and -7.8% (P<0.01) and after 24 wk -21.82% and -17% (P<0.01) with no changes in the EX group. After 12 and 24 wk, VO2 max was increased by 21.81-39.54% (P<0.05) in the EXD group and 18.09-40.95% in the EX group with no changes in the DI group. In the EXD and DI groups, circulating levels of TNF-a and IL-6 were decreased after 24 wk for both groups (P<0.01). No changes in the EX group. HOMA-R decreased (P<0.05) only after 24 wk in the EXD group. In AT biopsies, subjects in the EXD and DI groups exhibited a significant decrease in MO (P<0.01 for all). No changes in AT biopsies were found in the EX group. In conclusion, chronic aerobic exercise was found to have no effects on circulating and AT MOI despite an increased VO2 max. Rather important body composition modifications were found to have beneficial effects on circulating and AT MOI in these obese women.

Author information

Correspondence to N Lakhdar.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark


  • Adipose Tissue
  • Body Composition
  • Inflammatory Marker
  • Obese Subject
  • Aerobic Exercise