Skip to main content
  • Poster presentation
  • Open access
  • Published:

Quality of life in children with familial Mediterranean fever


Familial Mediterranean fever (FMF) is a lifelong disorder, characterized by self-limited and recurrent attacks of fever and polyserositis. It is known that many chronic diseases have a negative effect on quality of life (QoL) multidimensionally. In our study, we aimed to assess the quality of life and psychological factors (anxiety and depression) in children with FMF.


A prospective cross-sectional study was conducted between September 2013 and September 2014. A total of 70 consecutive children with FMF who were diagnosed according to the Tel-Hashomer and Yalçınkaya criteria during the attack free period and 70 healthy children who were matched in terms of age and sex were enrolled. The Pediatric Quality of Life Inventory 4.0 (PedsQLTM 4.0), Child Depression Inventory (CDI) and Screen for Child Anxiety and Related Disorders (SCARED) were used for the psychosocial assessment.


Mean age of the patients (27 girls and 43 boys) was 11±3 years. The physical health, psychosocial health and total summary scores of the children with FMF were significantly lower than healthy children. In terms of sub dimension of psychosocial health, in the children with FMF, emotional functioning and school functioning domains’ scores were significantly lower than healthy children. Depression and anxiety scores were higher in the children with FMF than in healthy children.

Table 1


We found that the children with FMF have high level of depression and poorer QoL. FMF is a life-long disorder that has not only physical but also psychosocial impairments for the affected children. Therefore a biopsychosocial approach should be essential to treatment of the FMF.

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Öztürk, Ö., Yüksel, S., Karadağlı, E. et al. Quality of life in children with familial Mediterranean fever. Pediatr Rheumatol 13 (Suppl 1), P130 (2015).

Download citation

  • Published:

  • DOI: