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L-ficolin and H-ficolin in patients with Familial Mediterranean fever

In the present study we performed comparative determination of the blood levels of L-ficolin and H-ficolin, opsonins and the initial components of the complement lectin pathway, in patients with Familial Mediterranean fever (FMF) in attack and attack-free periods and healthy subjects. In addition, in all study subjects serum levels of IL-1b and and total leukocyte count (TLC) were determined. Fifty FMF-affected subjects (female/male: 25/25; mean age ± SD: 31.3 ± 11; in attack/attack free: 23/27) and 81 age- and sex-matched healthy subjects (control group) without family history of FMF or other autoinflammatory diseases were enrolled in this study. Elevated H-ficolin level and TLC were detected in patients during attack period, whereas increased levels of L-ficolin and IL-1b were found in both attack and attack free patients with higher values during attack. Positive correlation between H-ficolin and L-ficolin levels in patients and healthy subjects was detected. Our results suggest excess production of L- and H-ficolins and increased apoptosis rate in FMF and indicate that H-ficolin is operating during development of acute autoinflammatory reactions, whereas L-ficolin is operating in both acute and subclinical autoinflammatory responses associated with this disease.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Mkrtchyan, G., Boyajyan, A. L-ficolin and H-ficolin in patients with Familial Mediterranean fever. Pediatr Rheumatol 13 (Suppl 1), P101 (2015).

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