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L-ficolin and H-ficolin in patients with Familial Mediterranean fever

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In the present study we performed comparative determination of the blood levels of L-ficolin and H-ficolin, opsonins and the initial components of the complement lectin pathway, in patients with Familial Mediterranean fever (FMF) in attack and attack-free periods and healthy subjects. In addition, in all study subjects serum levels of IL-1b and and total leukocyte count (TLC) were determined. Fifty FMF-affected subjects (female/male: 25/25; mean age ± SD: 31.3 ± 11; in attack/attack free: 23/27) and 81 age- and sex-matched healthy subjects (control group) without family history of FMF or other autoinflammatory diseases were enrolled in this study. Elevated H-ficolin level and TLC were detected in patients during attack period, whereas increased levels of L-ficolin and IL-1b were found in both attack and attack free patients with higher values during attack. Positive correlation between H-ficolin and L-ficolin levels in patients and healthy subjects was detected. Our results suggest excess production of L- and H-ficolins and increased apoptosis rate in FMF and indicate that H-ficolin is operating during development of acute autoinflammatory reactions, whereas L-ficolin is operating in both acute and subclinical autoinflammatory responses associated with this disease.

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Correspondence to G Mkrtchyan.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Keywords

  • Family History
  • Serum Level
  • Healthy Subject
  • Blood Level
  • Familial Mediterranean Fever