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Plasma exchange therapy for severe gastrointestinal involvement of Henoch Schonlein purpura in children

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Pediatric Rheumatology201412 (Suppl 1) :P357

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  • Vasculitis
  • Nephritis
  • Glomerulonephritis
  • Purpura
  • Plasma Exchange


Henoch-schönlein purpura (HSP), which is predominantly a disease of childhood, is a small vessel vasculitis. It is characterized by non-thrombocytopenic purpura, arthritis and arthralgia, abdominal pain, gastrointestinal hemorrhage and glomerulonephritis. Prognosis and treatment opportunities depends on the clinical severity and organ involvement. Some reports have been published suggesting the beneficial effects of plasma exchange in HSP nephritis, but there have been only some small case series discussing the efficacy of plasma exchange in gastrointestinal system (GIS) involvement.


The aim of this report is to evaluate the plasma exchange as a choice for the treatment of life threating GIS ınvolvement in HSP when refractory to conventional therapies.


We respectively reviewed the medical records of HSP patients whom had plasma exchange therapy due to massive GIS involvement. We reported age, gender, initial HSP presentation, etiological or triggering factors and disease course. Treatment modalities, side effects and their outcomes were noted.


Seven patients who had plasma exchange therapy due to GIS involvement were identified. All patients had pulse methylprednisolone (MPZ) treatment and then continued with oral prednisolone (2mg/kg/day) therapy. All patients’ complaints continued, GI bleeding and the severity of disease did not improve. Therefore, pulse cyclophosphamide was added to the treatment. Two patients received intravenous immunoglobulin (IVIG) therapy. Gastrointestinal manifestations did not improved and plasma exchange was performed. All patients improved after plasma exchange management.


Treatment of GI involvement in HSP with plasma exchange have been mainly based on case reports. According to our data, we propose that, plasma exchange may be a safe and efficient management choice in pediatric HSP patients with massive GIS involvement

Disclosure of interest

None declared

Authors’ Affiliations

Pediatric Nephrology and Rheumatology, Ankara Child Health Hematology Oncology Education and Research Hospital, Ankara, Turkey
Pediatric Hematology, Ankara Child Health Hematology Oncology Education and Research Hospital, Ankara, Turkey


© Basaran et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.