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Prospective analysis of Kawasaki disease cases in Catalonia (Spain) from March 2013 to March 2014
Pediatric Rheumatology volume 12, Article number: P349 (2014)
Introduction
Kawasaki disease (KD) is an acute self-limited systemic vasculitis relatively common in childhood. In Japan, last published survey shows an incidence up to 239.6/105 children <5 years old (yo). In Madrid (Spain) a retrospective study with no well defined reference area showed an incidence of 15.1/105 children <5yo.
Objectives
To ascertain the incidence and clinical features of KD in Catalonia Catalonia, autonomous region in northeast Spain with 7.5 million inhabitants, over a prospective period of one year.
Methods
Observational population-based study including all Catalan hospitals with Pediatric Units, both public and private management. Prospective communication of new cases of KD was performed from March 2013 to March 2014. The presence of coronary aneurysms (CA) in echocardiology was based in the body surface area according to the American Heart Association. Giant CA was considered if the CA was higher than 8mm.
Results
The study included 33 different hospitals from Catalonia. Over the one-year study period 49 new cases of KD were collected. The annual incidence was 4.1/105 children <14yo and 12.3/105 children <5yo (mean age 34±23months (m), range 3.3-105.1m). There were not differences between boys and girls. Mean delay between onset of the disease and diagnostic was 8.6±9.8 days. Ethnic distribution was: Caucasian 42 patients (85.7%), North African 4 (8.1%), Amerindian 2 (4%) and Asian 1 (2%). Distribution of classical manifestations for KD was: fever in 100% of patients, changes in extremities: edema and erythema 51%% and desquamation 44.9%, exanthema 85.7%, conjunctival injection 91.8%, changes in lips and oral cavity 77.5% and lymphadenopathy 24.8%. Other clinical findings reported were: sterile pyuria in 10 (20%) patients, nausea and vomiting in 13 (26.5%), abdominal pain in 12 (24.4%), gallbladder distention in 1 (2%), transaminase elevation in 13 (26.5%), jaundice in 3 (6.1%), irritability in 20 (40.8%), and arthritis or arthralgia in 13 (26.5%). Cardiologic findings were: perivascular brightness of the coronary wall in 8 (16.3%) patients, myocarditis in 1 (2%), mitral regurgitation in 3 (6%) and CA in 8 (16.3%) patients, disappearing before the 2nd moth of disease in 2 patients. No gyant CA were reported. Intravenous immunoglobulin (IVIG) was administered in 47 (95.9%) patients with response to the 1st dose in 40 (91.6%). Day of IVIG administration was 7.8±3.3. Abciximab was administered in 2 patients. 97.9% of patients received anti-platelet dose aspirin in the convalescent phase.
Conclusion
During the prospective period incidence of KD in Catalonia (Spain) was higher than the one ascertained in the retrospective analysis. Further analysis may be performed in order to know if this is due to a better diagnosis, a better registry o a real incidence increase. It seems to be a higher incidence of CA in our cohort despite high rates of treatment response. Further analysis is required. Incidence rate, other clinical features and treatment plans are similar to dose described in studies in other European countries.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Sanchez-Manubens, J., Anton, J., Prada, F. et al. Prospective analysis of Kawasaki disease cases in Catalonia (Spain) from March 2013 to March 2014. Pediatr Rheumatol 12 (Suppl 1), P349 (2014). https://doi.org/10.1186/1546-0096-12-S1-P349
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DOI: https://doi.org/10.1186/1546-0096-12-S1-P349
Keywords
- Myocarditis
- Mitral Regurgitation
- Kawasaki Disease
- Abciximab
- Pyuria