Skip to main content
  • Poster presentation
  • Open access
  • Published:

Polyarticular juvenile idiopathic arthritis (pJIA): clinical and serologic predictors of inactive disease (ID)


Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood and the polyarticular subtype is associated with persistent activity and a low rate of remission. The goal of an early and aggressive treatment is to achieve remission preventing irreversible joint destruction and long-term disabilities.


  1. 1)

    To assess disease activity in patients with pJIA “under early therapy with MTX.”

  2. 2)

    To determine predictors of ID in this cohort.


Clinical charts of 174 pJIA pts (ILAR´01), (1998 -2009) we reviewed. Inclusion criteria:-pJIA pts under “early” MTX–follow up “a minimum of 12mo”. Demographic, clinical, laboratory, and therapeutic variables were analyzed at disease onset, 12mo and last visit. Functional disability(CHAQ), damage (JADI Articular score) and Remission Criteria (Wallace) were properly assesed.


Ninety eight patients were included , 85 girls, (86.7%) median age at onset 10 years ( IQR :6 -12) ,median disease duration 60 months ( IQR :36 -74 ) and follow-up 48 months (IQR :24,5 -67) ; 34 pts (34.6%) were RF Positive. All patients received MTX; 32 /98 (32.6%) reached ID at amedian follow up time of 12 mo with a CHAQ mean value 0,37 and a JADI mean value 1,3. Nineteen out these 32 pts (60%) sustained remission for at least 37 mo. ID was associated with a less time of disease evolution (p.05), a better function CHAQ (p .05) and less damage (p .04)A higher prevalence but not significantly RF titers (40 vs 25%); seronegative ANA titers (60 vs 53 ) and RX damage (47 vs 32 ) were observed in the group of non responders pts to MTX. On multivariate analysis a less time of disease evolution was the only predictive risk factor associated to inactive disease (β 1,01 p .05).


In our series , only 32/98 (32.6%) pJIA pts reached ID , this clinical state was sustained in 60% of them longer than 2 years. A less interval between disease onset and Mtx start was the only variable predicting inactive disease.

Disclosure of interest

None declared.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Meiorin, S. Polyarticular juvenile idiopathic arthritis (pJIA): clinical and serologic predictors of inactive disease (ID). Pediatr Rheumatol 12 (Suppl 1), P196 (2014).

Download citation

  • Published:

  • DOI: