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Volume 12 Supplement 1

Proceedings of the 21st European Pediatric Rheumatology (PReS) Congress

Superoxide dismutase and and its isoenzymes in children with juvenile idiopathic arthritis

Pediatric Rheumatology volume 12, Article number: P158 (2014) Cite this article

Introduction

Juvenile idiopathic arthritis (JIA) is not a rare disease in children. The etiology of the disease is unknown and various parameters are useful in establishing diagnosis. The research concerning reactive oxygen species in recent years shows that chronic oxidative stress may lead to chronic inflammation. Among the antioxidant systems present in cells superoxide dismutase is one of the preventive antioxidants i.e. enzymes reducing the number of generated free radicals.

Objectives

The aim of the study was to examine the levels of superoxide dismutase and it’s isoenzymes in blood serum of JIA patients and healthy ones. Moreover levels’ changes in serum in children with inflammation of the joints depending on disease’s activity were investigated.

Methods

The studied parameters were measured in blood serum of 59 patients with JIA, age from 2 to 18 years old, hospitalized in the Rheumatology Division of the Department of Pediatrics in Zabrze, in Silesian Medical University. The control group consisted of 25 healthy children.

Results

The superoxide dismutase and it’s izoenzymes’ activity do not depend on JIA type.

Mn type superoxide dysmutase activity in acute phase in JIA patients is significantly higher in comparison to its activity in remission.

Conclusion

Activity of superoxide dysmutase in blood serum in children with JIA depends on disease’s phase.

Disclosure of interest

None declared.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Zabrze, Medical University Of Silesia, Katowice, Poland

    Henryka Mazur Zielinska, Michal Zielinski, Lukasz Pilarz & Dorota Karbowska

  2. Department of Biochemistry, Zabrze, Medical University Of Silesia, Katowice, Poland

    Ewa Birkner

Authors
  1. Henryka Mazur Zielinska
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  2. Michal Zielinski
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  3. Lukasz Pilarz
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  4. Dorota Karbowska
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  5. Ewa Birkner
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cite this article

Zielinska, H.M., Zielinski, M., Pilarz, L. et al. Superoxide dismutase and and its isoenzymes in children with juvenile idiopathic arthritis. Pediatr Rheumatol 12 (Suppl 1), P158 (2014). https://doi.org/10.1186/1546-0096-12-S1-P158

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  • DOI: https://doi.org/10.1186/1546-0096-12-S1-P158

Keywords

  • Oxidative Stress
  • Reactive Oxygen Species
  • Superoxide Dismutase
  • Acute Phase
  • Chronic Inflammation

Pediatric Rheumatology

ISSN: 1546-0096